Anti-MPC1 Rabbit Polyclonal Antibody
Product#: SB-GB112414
$560.00
Availability:
Ships in 1-2 Weeks
Anti-MPC1 Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB112414 |
| Size | ：100 uL |
| Protein full name | ：Mitochondrial pyruvate carrier 1 |
| Synonym | ：Brain protein 44-like protein, Mpc1, Brp44l, CGI129, HSPC040, PNAS115 |
| Immunogen | ：KLH conjugated Synthetic peptide corresponding to Mouse MPC1 |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Predicted MW. | ：12 kDa |
| Observed MW. | ：12 kDa |
| Uniprot ID | ：P63030, P63031 |
| Long Term Storage | ：-20 ℃ or below |
| Shipping Condition | ：Dry Ice |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| WB | Mouse, Rat | 1: 500-1: 1000 |
heart, liver, kidney |
Description
The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene.
 |
Western blot analysis of MPC1 (GB112414) at dilution of 1: 1000 Lane 1: Mouse heart tissue lysate Lane 2: Mouse liver tissue lysate Lane 3: Mouse kidney tissue lysate Lane 4: Rat heart tissue lysate Lane 5: Rat kidney tissue lysate |
Antigen Characterization
- Type: Primary
- Application: Western Blot (WB),Immunohistochemistry (IHC),Immunocytochemistry/Immunofluorescence (ICC/IF),Enzyme-Linked Immunosorbent Assay (ELISA)
- Species: Human
- Recombinant: Yes
Human Diseases
- Lung Adenocarcinoma: Low expression of MPC1 is associated with poor prognosis and increased tumor progression. It interacts with mitochondrial STAT3, inhibiting its phosphorylation, which is linked to reduced malignancy in lung cancer cells.
- Colon Cancer: MPC1 deficiency promotes aerobic glycolysis and malignant progression.
- Prostate Cancer: Decreased MPC1 levels correlate with poor patient outcomes.
Cellular Signaling Pathways
- STAT3 Pathway: MPC1 interacts with mito-STAT3, disrupting its distribution and reducing cytoplasmic STAT3 activation, which plays a critical role in tumor progression.
- Glycolytic Pathway: Involved in the regulation of pyruvate transport into mitochondria, affecting cellular metabolism and energy production.
- T Cell Development Pathways: Essential for normal thymic development of T cells, influencing immune responses.
Aliases for MPC1 Gene
- GeneCards Symbol: MPC1 2
- Mitochondrial Pyruvate Carrier 1 2 3 4 5
- CGI-129 2 3 5
- SLC54A1 2 3 5
- BRP44L 3 4 5
- Brain Protein 44-Like Protein 3 4
- DJ68L15.3 2 5
- Brain Protein 44-Like 2
- HSPC040 Protein 3
- MPYCD 3
References
- Zou, Hongbo, et al. “MPC1 Deficiency Accelerates Lung Adenocarcinoma Progression through the Stat3 Pathway.” Nature News, Nature Publishing Group, 15 Feb. 2019, www.nature.com/articles/s41419-019-1324-8.
- Ramstead, Andrew G, et al. “Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.” Cell Reports, U.S. National Library of Medicine, 3 Mar. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7170217/.
- Anti-MPC1 Antibody.” Abcam, www.abcam.com/en-us/products/primary-antibodies/mpc1-antibody-ab74871.
- MPC1 Protein Expression Summary - the Human Protein Atlas, www.proteinatlas.org/ENSG00000060762-MPC1.
- Account - Genecards Suite, www.genecards.org/cgi-bin/carddisp.pl?gene=MPC1.
