Anti-MMP13 Rabbit Polyclonal Antibody (WB)
Product#: SB-GB11247-1
$560.00
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Anti-MMP13 Rabbit Polyclonal Antibody (WB)
General information
| Cat. No. | ：SB-GB11247-1 |
| Size | ：100 uL |
| Protein full name | ：Collagenase 3 |
| Synonym | ：Collagenase 3, MMP13, CLG3, MANDP1, MMP-13, Matrix metallopeptidase 13, MDST |
| Immunogen | ：KLH conjugated Synthetic peptide corresponding to Mouse MMP13 |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Predicted MW. | ：54 kDa |
| Observed MW. | ：54 kDa |
| Uniprot ID | ：P33435, P45452 |
| Long Term Storage | ：-20 ℃ or below |
| Shipping Condition | ：Dry Ice |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| WB | Human, Mouse | 1: 500-1: 1000 |
liver cancer, stomach cancer, skin |
Description
Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
 |
Western blot analysis of MMP13 (GB11247-1) at dilution of 1:800. Lane 1:HeLa cell lysate Lane 2:MCF7 cell lysate Lane 3:HepG2 cell lysate Lane 4:Human liver cancer tissue lysate Lane 5:Human stomach cancer tissue lysate Lane 6:Mouse skin tissue lysate Lane 7:Rat skin tissue lysate |
Antigen Characterization
- Type: Primary
- Application: ELISA,Western Blot,Immunohistochemistry (IHC),Immunoprecipitation (IP)
- Species: Human, Mouse, Rat,Rabbit
- Recombinant: Yes
Human Diseases
- Spondyloepimetaphyseal Dysplasia, Missouri Type: A genetic disorder affecting bone growth and development.
- Metaphyseal Anadyplasia 1: A skeletal dysplasia characterized by short stature and skeletal abnormalities.
- Metaphyseal Dysplasia, Sphar Type: Another form of skeletal dysplasia affecting bone morphology and growth.
Cellular Signaling Pathways
- Wnt Signaling Pathway: MMP13 is involved in the degradation of extracellular matrix components, influencing cell signaling related to development and tissue remodeling.
- TGF-β Signaling Pathway: MMP13 can modulate TGF-β activity, which is crucial for various cellular processes including proliferation and differentiation.
- Integrin Signaling: MMP13 interacts with integrins, affecting cell adhesion and migration during wound healing and tissue repair.
Aliases for MMP13 Gene
- GeneCards Symbol: MMP13 2
- Matrix Metallopeptidase 13 2 3 5
- Collagenase 3 2 3 4
- CLG3 2 3 5
- Matrix Metalloproteinase 13 (Collagenase 3) 2 3
- MMP-13 3 4
- Matrix Metalloproteinase-13 4
- EC 3.4.24.35 49
- EC 3.4.24.22 49
- EC 3.4.24.24 49
- EC 3.4.24.65 49
- EC 3.4.24.- 4
- EC 3.4.24.7 49
- EC 3.4.24 49
- MANDP1 3
- MDST 3
References
- Duncan, Henry F., et al. “The Critical Role of MMP13 in Regulating Tooth Development and Reactionary Dentinogenesis Repair through the Wnt Signaling Pathway.” Frontiers, Frontiers, 14 Mar. 2022, www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2022.883266/full.
- Wang, Meina, et al. “MMP13 Is a Critical Target Gene during the Progression of Osteoarthritis - Arthritis Research & Therapy.” BioMed Central, BioMed Central, 8 Jan. 2013, arthritis-research.biomedcentral.com/articles/10.1186/ar4133.
- MMP-13 Inhibitor - CAS 544678-85-5 - Calbiochem | 444283, www.merckmillipore.com/INTL/en/product/MMP-13-Inhibitor-CAS-544678-85-5-Calbiochem,EMD_BIO-444283.
- Kumar, Purushottam, et al. “The Role of Matrix Metalloproteinase 13 and Vitamin D in Osteoarthritis: A Hospital-Based Observational Study.” Cureus, U.S. National Library of Medicine, 18 Sept. 2023, www.ncbi.nlm.nih.gov/pmc/articles/PMC10582788/.
- A, Oranger, et al. “Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing.” (MA5-14238), www.thermofisher.com/antibody/product/MMP13-Antibody-clone-VIIIA2-Monoclonal/MA5-14238.
