Anti-MYL6 Rabbit Polyclonal Antibody
Product#: SB-GB112598
$779.20
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Anti-MYL6 Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB112598 |
| Size | ：100 uL |
| Protein full name | ：Myosin light polypeptide 6 |
| Synonym | ：17 kDa myosin light chain, LC17, Myosin light chain 3, MLC-3, Myosin light chain alkali 3, Myosin light chain A3, Smooth muscle and nonmuscle myosin light chain alkali 6, Myl6, Myln |
| Immunogen | ：Recombinant protein corresponding to Mouse MYL6 |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Subcellular location | ：Cytoskeleton |
| Uniprot ID | ：Q64119 |
| Long Term Storage | ：-20 ℃ or below |
| Shipping Condition | ：Dry Ice |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| IHC | Rat | 1: 2000-1: 4000 |
bladder, heart |
Description
Regulatory light chain of myosin. Does not bind calcium.
 |
Immunohistochemistry analysis of paraffin-embedded rat bladder using MYL6 (GB112598) at dilution of 1: 4000 |
 |
Immunohistochemistry analysis of paraffin-embedded rat heart using MYL6 (GB112598) at dilution of 1: 4000 |
Antigen Characterization
- Type: Primary
- Application: ELISA,Western Blot,IHC
- Species: Human
- Recombinant: Yes
Human Diseases
- Microscopic Polyangiitis: MYL6 has been identified as an antigen associated with this autoimmune disease, influencing neutrophil extracellular trap (NET) formation.
- Cardiovascular Diseases: Altered expression of MYL6 is implicated in various cardiovascular conditions due to its role in muscle contraction.
- Muscle Disorders: MYL6 is essential for normal muscle function and development.
Cellular Signaling Pathways
- Muscle Contraction Pathway: MYL6 plays a crucial role in the contraction of skeletal and cardiac muscles through interaction with myosin.
- Calcium Signaling Pathway: It is involved in calcium-mediated signaling, which is vital for muscle contraction and relaxation processes.
- Regulation of Gene Expression: MYL6 may influence transcriptional regulation in muscle cells.
Aliases for MYL6 Gene
- GeneCards Symbol: MYL6 2
- Myosin Light Chain 6 2 3 5
- MLC3NM 2 3 5
- MLC1SM 2 3 5
- ESMLC 2 3 5
- Myosin, Light Polypeptide 6, Alkali, Smooth Muscle And Non-Muscle 2 3
- Myosin, Light Chain 6, Alkali, Smooth Muscle And Non-Muscle 2 3
- Myosin Light Chain Alkali 3 3 4
- Myosin Light Polypeptide 6 3 4
- 17 KDa Myosin Light Chain 3 4
- Myosin Light Chain A3 3 4
- MLC-3 3 4
- LC17 3 4
- Smooth Muscle And Nonmuscle Myosin Light Chain Alkali 6 4
- Myosin Light Chain 3 4
- LC17-GI 3
- LC17-NM 3
- MLC3SM 3
- LC17A 3
- LC17B 3
References
- Immune Cell - MYL6 - the Human Protein Atlas, Human Protein Atlas, www.proteinatlas.org/ENSG00000092841-MYL6/immune+cell.
- Tissue Expression of Myl6 - Summary - The Human Protein Atlas, Human Protein Atlas, www.proteinatlas.org/ENSG00000092841-MYL6/tissue.
- Database, Rat Genome. MYL6 (Myosin Light Chain 6) - Rat Genome Database, rgd.mcw.edu/rgdweb/report/gene/main.html?id=1589019.
- MYL6 Myosin Light Chain 6 [Homo Sapiens (Human)] - Gene - NCBI.” National Center for Biotechnology Information, U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/gene?Cmd=DetailsSearch&Db=gene&Term=4637.
- MYL6B Myosin Light Chain 6b [Homo Sapiens (Human)] - Gene - NCBI.” National Center for Biotechnology Information, U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/gene?Cmd=DetailsSearch&Db=gene&Term=140465.