Anti-MX1 Rabbit Polyclonal Antibody
Product#: SB-GB112553
$779.20
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Anti-MX1 Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB112553 |
| Size | ：100 uL |
| Protein full name | ：Interferon-induced GTP-binding protein Mx1 |
| Synonym | ：Influenza resistance protein, Myxoma resistance protein 1, Myxovirus resistance protein 1, Mx1, Mx, IFI78K |
| Immunogen | ：KLH conjugated Synthetic peptide corresponding to Mouse MX1 |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Predicted MW. | ：72 kDa |
| Observed MW. | ：72 kDa |
| Uniprot ID | ：P20591, P09922, P18588 |
| Long Term Storage | ：-20 ℃ or below |
| Shipping Condition | ：Dry Ice |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| WB | Human, Mouse, Rat | 1: 800-1: 1600 |
kidney, liver |
Description
The Dynamin family of microtubule-associated proteins function as GTPases that are involved in microtubule bundling and endocytosis. In mice, Mx1 (myxovirus resistance protein 1) is member of the Dynamin family that is involved in the immune response to viral infections. Localized to the cytoplasm, Mx1 is localized to the nucleus where, upon induction by IFN-alpha/IFN-beta, it provides selective resistance to infection by the highly lethal H5N1 influenza virus. In humans, MxA and MxB function in a similar manner to Mx1 and Mx2, conferring resistance to specific target viruses. Mx3 is a rat-specific member of the myxovirus resistance protein family.
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Western blot analysis of MX1 (GB112553) at dilution of 1: 1600 Lane 1: HeLa cell lysate Lane 2: Raji cell lysate Lane 3: HepG2 cell lysate Lane 4: Mouse kidney tissue lysate Lane 5: Rat kidney tissue lysate Lane 6: Rat liver tissue lysate |
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Western blot analysis of MX1 (GB112553) at dilution of 1: 1600 Lane 1: HeLa cell lysate Lane 2: A431 cell lysate Lane 3: A549 cell lysate Lane 4: HepG2 cell lysate Lane 5: H1299 cell lysate Lane 6: Mouse kidney tissue lysate Lane 7: Rat kidney tissue lysate |
Antigen Characterization
- Type: Primary
- Application: Western Blot (WB),Immunohistochemistry (IHC),Immunocytochemistry (ICC),Enzyme-Linked Immunosorbent Assay (ELISA),Immunoprecipitation (IP)
- Species: Human, Mouse, Rat
- Recombinant: Yes
Human Diseases
- Viral Infections: Plays a crucial role in the immune response against various viral infections, including influenza and hepatitis B
- Cancer: Implicated in tumor biology; expression levels can influence tumor progression and response to therapies
- Autoimmune Disorders: Altered expression may be linked to autoimmune conditions
Cellular Signaling Pathways
- Interferon Signaling Pathway: Induced by type I interferons; enhances MX1 expression to exert antiviral effects .
- NF-kB Pathway: Involved in inflammatory responses; modulation of MX1 can influence NF-kB activity and downstream effects on immune responses .
- GTPase Activity: Functions as a GTPase, impacting cellular signaling related to viral resistance
Aliases for MX1 Gene
- GeneCards Symbol: MX1 2
- MX Dynamin Like GTPase 1 2 3 5
- IFI-78K 2 3 4 5
- LncMX1-215 2 3 5
- MxA 2 3 5
- Interferon-Regulated Resistance GTP-Binding Protein MxA 3 4
- Interferon-Induced GTP-Binding Protein Mx1 3 4
- Interferon-Inducible Protein P78 2 3
- Interferon-Induced Protein P78 3 4
- Myxoma Resistance Protein 1 3 4
- Myxovirus (Influenza) Resistance 1, Homolog Of Murine (Interferon-Inducible Protein P78) 2
- Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein P78 (Mouse) 2
- Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein P78 3
- Myxovirus Resistance Protein 1 4
- IFI78 3
- MX 3
References
- MX1 Antibody (ABIN7442714).” MX1 Antibody (ABIN7442714), www.antibodies-online.com/antibody/6999040/anti-Myxovirus+Resistance+Protein+1+MX1+AA+68-303+antibody/.
- 13750-1-AP.” MX1 Antibody (13750-1-AP) | Proteintech, 21 Sept. 2024, www.ptglab.com/products/MX1-Antibody-13750-1-AP.htm.
- Anti-MX1 Antibody.” Abcam, www.abcam.com/en-us/products/primary-antibodies/mx1-antibody-ab95926.
- MX1 Antibodies from Thermo Fisher Scientific.” Anti-MX1 Antibodies | Invitrogen, 12 Feb. 2023, www.thermofisher.com/antibody/primary/target/mx1.
- Human Mxa/Mx1 Antibody.” Www.Rndsystems.Com, www.rndsystems.com/products/human-mxa-mx1-antibody_af7946. .
- Stubby, et al. “Mx1/2/3 Antibody (C-1): SCBT - Santa Cruz Biotechnology.” SCBT, 24 Jan. 2023, www.scbt.com/p/mx1-2-3-antibody-c-1.
