Anti-MCT8 Rabbit Polyclonal Antibody
Product#: SB-GB112452
$560.00
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Anti-MCT8 Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB112452 |
| Size | ：100 uL |
| Protein full name | ：Monocarboxylate transporter 8 |
| Synonym | ：MCT8, Solute carrier family 16 member 2, X-linked PEST-containing transporter, Slc16a2, Mct8, Xpct |
| Immunogen | ：KLH conjugated Synthetic peptide corresponding to Mouse MCT 8 |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Predicted MW. | ：60 kDa |
| Observed MW. | ：55 kDa |
| Uniprot ID | ：P36021, O70324, Q8K1P8 |
| Long Term Storage | ：-20 ℃ or below |
| Shipping Condition | ：Dry Ice |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| WB | Human, Mouse, Rat | 1: 500-1: 1000 |
skeletal muscle, brain, heart |
Description
Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr.
 |
Western blot analysis of MCT 8 (GB112452) at dilution of 1: 1000 Lane 1: 293T cell lysate Lane 2: Mouse skeletal muscle tissue lysate Lane 3: Rat brain tissue lysate Lane 4: Rat heart tissue lysate |
Antigen Characterization
- Type: Primary
- Application: ELISA,Western Blot,Immunofluorescence
- Species: Human, Mouse, Rat
- Recombinant: Yes
Human Diseases
- Allan-Herndon-Dudley Syndrome (AHDS): An X-linked condition characterized by severe intellectual and motor disabilities due to mutations in the MCT8 gene, leading to impaired thyroid hormone transport in the brain. Patients exhibit symptoms like hypotonia, spasticity, muscle weakness, and cognitive impairment.
- Thyroid Hormone Transport Deficiency: Impacts neurological development and function
Cellular Signaling Pathways
- Thyroid Hormone Signaling: MCT8 facilitates the uptake of T3 into neurons, where it binds to thyroid hormone receptors (TR) that interact with retinoid X receptors (RXR), influencing gene transcription.
- AKT Pathway: MCT8's role in oligodendrocyte differentiation involves AKT phosphorylation, driving myelination processes.
- Neuronal Signaling: Affects neuronal health and development through thyroid hormone transportation
Aliases for MCT8 Gene
- GeneCards Symbol: SLC16A2 2
- Solute Carrier Family 16 Member 2 2 3 4 5
- XPCT 2 3 4 5
- MCT8 2 3 4 5
- MCT7 2 3 5
- Solute Carrier Family 16, Member 2 (Thyroid Hormone Transporter) 2 3
- X-Linked PEST-Containing Transporter 3 4
- Monocarboxylate Transporter 8 3 4
- Monocarboxylate Transporter 7 3 4
- DXS128 3 5
- MCT 7 3 4
- MCT 8 3 4
- MRX22 3 5
- AHDS 3 5
- Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 2 (Putative Transporter) 2
- Solute Carrier Family 16, Member 2 (Monocarboxylic Acid Transporter 8) 2
- Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 2 2
- Mental Retardation, X-Linked 22 2
- Allan-Herndon-Dudley Syndrome 2
- DXS128E 3
References
- Schwartz, Charles E, and Roger E Stevenson. “The MCT8 Thyroid Hormone Transporter and Allan-Herndon-Dudley Syndrome.” Best Practice & Research. Clinical Endocrinology & Metabolism, U.S. National Library of Medicine, June 2007, www.ncbi.nlm.nih.gov/pmc/articles/PMC2094733/.
- Groeneweg, Stefan, et al. “Insights into the Mechanism of MCT8 Oligomerization.” OUP Academic, Oxford University Press, 18 June 2020, academic.oup.com/jes/article/4/8/bvaa080/5859536.
- Roberts, Lori M., et al. “Expression of the Thyroid Hormone Transporters Monocarboxylate Transporter-8 (SLC16A2) and Organic Ion Transporter-14 (SLCO1C1) at the Blood-Brain Barrier.” OUP Academic, Oxford University Press, 1 Dec. 2008, academic.oup.com/endo/article/149/12/6251/2455433?login=false.
- Lee, Jae Young, et al. “Overcoming Monocarboxylate Transporter 8 (Mct8)-Deficiency to Promote Human Oligodendrocyte Differentiation and Myelination.” EBioMedicine, U.S. National Library of Medicine, Nov. 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5704066/.
- Porst, Theresa, et al. “Natural Autoimmunity to the Thyroid Hormone Monocarboxylate Transporters MCT8 and MCT10.” MDPI, Multidisciplinary Digital Publishing Institute, 30 Apr. 2021, www.mdpi.com/2227-9059/9/5/496.
