ICG Dichlorotriazine
Product#: POR2616
$3,716.00
Size of product (mg)
-
5 mg
-
25 mg
Availability:
Ships in 1-2 Weeks
ICG Dichlorotriazine
Cat. No. List below
Description
ICG Dichlorotriazine is a powerful near-infrared (NIR) fluorescent dye designed for advanced bioimaging applications. This hydroxyl-reactive compound offers exceptional properties that make it invaluable in various research fields.
The labeling process involves the displacement of one chlorine atom on the triazine ring by a hydroxyl group, resulting in an irreversible covalent bond. This reaction is highly specific and efficient, making ICG Dichlorotriazine an ideal choice for targeted labeling in complex biological systems.
ICG Dichlorotriazine's NIR fluorescence enables deep tissue imaging, allowing researchers to observe structures beneath the skin surface. This capability is particularly useful in In vivo imaging, tumor detection, and vascular mapping. The dichlorotriazine reactive group can directly label polysaccharides, alcohols on biomolecules, and other hydroxyl-containing compounds. This reaction occurs in aqueous solutions at pH > 9, forming a stable aryl ether linkage.
ICG Dichlorotriazine finds applications in numerous fields, including cellular labeling and detection, biomedical imaging, drug delivery tracking, tissue engineering, and cancer research.
ICG Dichlorotriazine represents a significant advancement in fluorescent labeling technology, offering researchers a powerful tool for exploring biological systems with unprecedented depth and clarity.
ICG Dichlorotriazine offers several advantages over similar products:
1. Hydroxyl Reactivity: Unique ability to directly label polysaccharides and alcohols in aqueous solutions, forming stable covalent bonds, unlike many other dyes that require additional coupling agents or steps.
2. Near-Infrared (NIR) Fluorescence: Operates at 785/812 nm, providing deep tissue imaging capabilities with minimal autofluorescence, surpassing visible-spectrum dyes like blue or green dyes.
3. High Stability: Generates a stable fluorescence signal and resists photobleaching when stored properly, unlike some water-soluble ICG derivatives that degrade over time.
4. Versatile Applications: Excitable by 750-800 nm laser or LED, making it suitable for a wide range of bioimaging and labeling applications, including cellular detection and deep tissue studies
The labeling process involves the displacement of one chlorine atom on the triazine ring by a hydroxyl group, resulting in an irreversible covalent bond. This reaction is highly specific and efficient, making ICG Dichlorotriazine an ideal choice for targeted labeling in complex biological systems.
ICG Dichlorotriazine's NIR fluorescence enables deep tissue imaging, allowing researchers to observe structures beneath the skin surface. This capability is particularly useful in In vivo imaging, tumor detection, and vascular mapping. The dichlorotriazine reactive group can directly label polysaccharides, alcohols on biomolecules, and other hydroxyl-containing compounds. This reaction occurs in aqueous solutions at pH > 9, forming a stable aryl ether linkage.
ICG Dichlorotriazine finds applications in numerous fields, including cellular labeling and detection, biomedical imaging, drug delivery tracking, tissue engineering, and cancer research.
ICG Dichlorotriazine represents a significant advancement in fluorescent labeling technology, offering researchers a powerful tool for exploring biological systems with unprecedented depth and clarity.
ICG Dichlorotriazine offers several advantages over similar products:
1. Hydroxyl Reactivity: Unique ability to directly label polysaccharides and alcohols in aqueous solutions, forming stable covalent bonds, unlike many other dyes that require additional coupling agents or steps.
2. Near-Infrared (NIR) Fluorescence: Operates at 785/812 nm, providing deep tissue imaging capabilities with minimal autofluorescence, surpassing visible-spectrum dyes like blue or green dyes.
3. High Stability: Generates a stable fluorescence signal and resists photobleaching when stored properly, unlike some water-soluble ICG derivatives that degrade over time.
4. Versatile Applications: Excitable by 750-800 nm laser or LED, making it suitable for a wide range of bioimaging and labeling applications, including cellular detection and deep tissue studies
Specifications
- Fluorophore: ICG
- Reactive group: Dichlorotriazine
- Excitation/Emission Max.(nm): 785/812
- Extinction coefficient: ≥ 218,000 cm-1M-1
- CF280: 0.05
- Appearance: Green Solid
- Molecular Weight: 920.99 g/mol
- Solubility: DMF, DMSO
- Storage conditions: -20 ℃, protect from light
| Quick link (Cat.#) | Series | Quick link (Cat.#) | Series |
| RFP0815 | ICG | RFP0915 | ICG (water-soluble) |
| POS1604 | ICG NHS ester | POA1616 | ICG Vinylsulfone |
| POSN1604 | ICG Sulfo-NHS ester | POI1616 | ICG Isothiocyanate |
| POC1616 | ICG Carboxylic acid | PWM1301 | ICG Maleimid |
| POE1616 | ICG Amine | PWT1301 | ICG Thiol |
| POR2616 | ICG Dichlorotriazine | POH1616 | ICG Hydrazide |
| POK1616 | ICG Alkyne | POG1616 | ICG PEG4-Alkyne |
| DOC1061 | ICG ADIBO | POZ1616 | ICG Azide |
Background
ICG Dyes
ICG is clinically approved NIR dye and used in medical diagnostics, in vitro, vivo and animal model study. NIR fluorescence allows to observe the deep image from the surface of skin and its usage spreads to a wide range of research fields. ICG fluorescence method is safe and cost effective technique and used in a wide range of medical fields such as breast cancer sentinel lymph node navigation, detecting cerebral vessels, coronary arteries and biliary trees, tracking tumor location, detecting small HCC, etc. The method has several advantages such as radiation free, compact instrumentation, real-time monitoring, easy operation, etc. The maximum excitation/emission values of ICG are 785/821 nm. When ICG is injected into a human body, it rapidly bound to plasma protein, mainly high-density lipoprotein, and generates red-shifted fluorescence (845 nm). ICG in aqueous solution is unstable over time, thus the fresh solution should be used for effective trials. BioActs provides ICG dye for biological research and medical diagnostics and also offers various reactive and functionalized ICG dyes for labeling of antibodies, peptides, proteins and ligands.
Table 1. ICG dye applications
Figure 1. Structure of Indocyanine Green (ICG) dye
Citation & Reference
1. Masashi Gotoh. Development of a canine model of pulmonary emphysema and imaging of the emphysematous lung with infrared thoracoscopy. J Thorac Cardiovasc Surg 126.6 (2003): 1916-21.
2. Aaron M. Mohs. An integrated widefield imaging and spectroscopy system for contrast-enhanced, image-guided resection of tumors. IEEE Trans Biomed Eng 62.5 (2015): 1416-24.
3. Mohammed Hassan. Near Infrared Fluorescence Imaging with ICG in TECAB Surgery Using the da Vinci Si Surgical System in a Canine Model. J Card Surg 27.2 (2012): 158-162.
4. R. C. Benson. Fluorescence properties of indocyanine green as related to angiography. Phys Med Biol 23.1 (1978): 159-63.
5. Mitsuharu Miwa. The Principle of ICG Fluorescence Method. The Open Surgical Oncology Journal 2 (2010): 26-28.
