Anti Human ER alpha mouse monoclonal antibody (H4624)
Anti Human ER alpha mouse monoclonal antibody (H4624)
ER alpha: Estorgen Receptor alpha
DiagnoCine offers excellent ER Alpha| Estrogen Receptor Alpha Antibodies to researchers studying Estrogenic responses, Estrogenic secretion, Hormonal gene regulation, Cellular Metabolism, Auto-immune Diseases, Cancer-associated Signal Transduction, and Cell Proliferation.
Human diseases include mammary tumor cells, autoimmune processing, breast cancer, endometrial cancer, osteoporosis, and endocrine-related neoplasm.
ER Alpha| Estrogen Receptor Alpha Antibodies has excellent quality and this highly pure antibody can be adapted for Western Blots, ELISA, Immunohistochemistry, Immunoprecipitation research with optimization.
General information
| Cat. No. | ：FNK-PP-H4624-00 |
| Size | ：100 ul |
| Antigen Species | ：Human |
| Host Species | ：Mouse |
| Cross Reactivity | ：Human |
| Purification | ：Ammonium sulfate fractionation |
| Clone No | ：H4624 |
| Lot. | ：A-1 |
| Concentration | ：1 mg/mL |
| Ig Class | ：G2a |
| Nomenclature | ：NR3A1 |
| Application | ：Western Blot (1 ug/mL) ：ELISA (0.3 ug/mL (A450=0.3)), ：IHC (10-20 ug/mL), ：IP (Decide by use), |
| Specificity |
：This antibody specifically recognizes humman ER alpha and cross reacts with mouse and rat ER alpha.
This antibody does not recognize human ER beta. |
| Storage | ：Store at 2 - 8 ºC up to one month. For long-term storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in a frost-free freezer is not recommended. |
| Form | ：Physiologic saline with 0.1 % NaN3 |
| Genbank | ：M12674 |
Description
Estrogen receptor alpha (ERa, ER; NR3A1) is a member of steroid receptor (AR, GR, MR, PR). The natural ligand for ER is the classical estrogenic compound 17b-estradiol. ERa is expressed in a wide variety of tissues. Expression was found at variable levels in bones, in uterus, bladder, ovary, prostate, testis, epididymys, kidney, breast, heart, vessel wall, pituitary and hypothalamus. ER has a variety of central physiological roles, including those involved in maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems. ERa has been shown to form homodimers as well as heterodimers with ERb. Both ERa and ERb can give rise to numerous isoforms.
Immunohistochemistry
Origin
Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human ER alpha (2-180 aa).
Notes
Sodium azide may react with lead and copper plumbing to form explosive metal azides. Flush with large amounts of water during disposal.
Aliases for ESR1 Gene
- Estrogen Receptor 1 2 3 5
- Nuclear Receptor Subfamily 3 Group A Member 1 2 3 4
- ER-Alpha 2 3 4
- NR3A1 2 3 4
- Oestrogen Receptor Alpha 2 3
- Estradiol Receptor 3 4
- E2 Receptor Alpha 2 3
- Estrogen Receptor 3 4
- ESR 3 4
- Era 2 3
- ER 3 4
- Estrogen Receptor Alpha E1-N2-E2-1-2 3
- Estrogen Receptor Alpha E1-E2-1-2 3
- Estrogen Nuclear Receptor Alpha 3
- Estrogen Receptor Alpha 2
- ESTRR 3
- ESRA 3
- ESR1 5
