Staurosporine, 5mg
Product#: FNK-BLK-0590-5mg
$792.62
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Staurosporine (5mg)
Cat No: FNK-BLK-0590-5mg
Product ID and Size
| Cat No. | Description | Size | Link |
| FNK-BLK-0590-100µg | Staurosporine | 100μg |  |
| FNK-BLK-0590-1mg | Staurosporine | 1mg | |
| FNK-BLK-0590-5mg | Staurosporine | 5mg | |
Description
Staurosporine was originally isolated from a culture broth of Saccharothrix aerocolonigenes subsp. staurosporeus AM-2282 while screening for microbial alkaloids. Staurosporine was discovered to have biological activities ranging from anti-fungal to anti-hypertensive1). The structure and absolute configuration of staurosporine was elucidated by X-ray crystallographic analysis 2–4). The first total synthesis was reported by Danishefsky et al5). Furthermore, Sturosporine was found to inhibit protein kinase C, IC50 =2.7 nM (rat brain)6) . Staurosporine was also found to be a potent relaxant of rabbit aortic strips contracted by various agonists7) . Staurosporine exerts it's biological effect by interacting, or binding, with a biological target such as a kinase through the prevention of ATP binding to the kinase. This is achieved through the stronger affinity of staurosporine to the ATP-binding site on the kinase. This image was obtained by crystallisation of the kinase with staurosporine followed by x-ray diffraction8) .
Staurosporine analogues, 7-Hydroxy-Staurosporine(UCN01) and N-Benzyl-Staurosporine(CGP 41251) are currently under clinical investigation as potential anticancer drugs9) .
Origin: from Saccharothrix aerocolonigenes subsp. staurosporeus AM-2282
CAS Registry Number: 62996-74-1
Appearance: Pale yellow crystals
Molecular Formula/ Weight: C28H26N4O3=466.20
Melting Point: 205-210˚C(dec.)
Purity: >98% by HPLC
Solubility: Sol. in DMSO, DMF, Slightly sol. in MeOH, Chloroform
Handling and Storage: Store at -20℃.
References:
- S. ?mura et al., J.Antibiot., 30, 275 (1977).
- A. Furusaki et al., J.Chem.Soc., Chem.Commun., 1978, 800 (1978).
- A. Furusaki et al., Bull Chem.Soc.Jpn., 55, 3681 (1982).
- N. Funato et al., Tetrahedron Lett., 35, 1251 (1994).
- J. T. Link et al., J.Am.Chem.Soc., 117, 552 (1995).
- T. Tamaoki et al., Biochem.Biophys.Res.Commun., 135, 397 (1986).
- Y. Sasaki et al., Eur.J.Phamacol., 202, 367 (1991).
- L. Prade, et al., Structure (London) 5, 1627-1637 (1997).
- G. Caravatti et al., Med.Chem.Lett., 4, 399 (1994).
- H. Nakano & S. ?mura, J.Antibiot., 62, 17 (2009).
