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Phepropeptin C Proteasome Inhibitor

Product#: FNK-16966

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Phepropeptin C Proteasome Inhibitor

Cat No.: FNK-16966
Size: 1mg

Specifications

Code No : 16966
CAS# : 396729-25-2
Molecular Formula : C38H60N6O6
Molecular Weight : 696.934
Source : Streptomyces sp. MK600-cF7
Appearance : Powder
Purity : > 98% (HPLC)
Long Term Storage : at - 20 °C
Solubility : Soluble in MeOH, DMSO, DMF
Insoluble in H2O

Application Notes
Phepropeptin C was isolated from cultured broth of Streptomyces sp. MK600-cF7 as an inhibitor of proteasome (IC50 value 12.5 μg/ml). It showed no inhibition toward proteasomal trypsin-like activityand α-chymotrypsin from bovine pancreas at 100 μg/ml.

Description
Phepropeptin C is a cyclic hexapeptide compound that functions as a proteasome inhibitor.It belongs to a family of four related compounds named phepropeptins A, B, C, and D, which were isolated for their ability to inhibit proteasomes, cellular structures that play a crucial role in regulating many cellular functions.

The structure of phepropeptins consists of six amino acid residues arranged in a cyclic configuration. While the exact structure of Phepropeptin C is not explicitly stated in the search results, we can infer that it shares similarities with Phepropeptin B, which has the structure cyclo(-L-Leu-D-Phe-L-Pro-L-Phe-D-Leu-L-Val-). The phepropeptins differ from each other in two of their constituent amino acids, while four amino acid moieties remain conserved across all four compounds.

Phepropeptins, including Phepropeptin C, demonstrate selective inhibition of the proteasomal chymotrypsin-like activity. Importantly, they do not inhibit alpha-chymotrypsin, indicating a specific action on proteasomes rather than a general protease inhibition.

Phepropeptin C is available commercially as a research tool for studying proteasome inhibition. It has a CAS number of 396729-25-2 and is typically supplied with high purity (>98%).

References
1) Isolation and structural determination of pheptopeptins A, B, C and D, new proteasome inhibitors produced by
Streptomyces sp. Sekizawa R, et al. J Antibiot. 2001 54(11) 874-881.

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Enzyme Inhibitors	Compound Name	Product Code	Link
Serine carboxypeptidase inhibitor	Belactin A	FNK-17736
Tyrosine hydroxylase inhibitor	Oudenone (Potassium Salt)	FNK-16640
Proteasome inhibitor	Phepropeptin A	FNK-16964
	Phepropeptin B	FNK-16965
	Phepropeptin C	FNK-16966	Current Link
	Phepropeptin D	FNK-16967
Angiotensin-converting enzyme (ACE) inhibitor	Foroxymithine	FNK-16968
Biological Activity on Cells and Organisms	Compound Name	Product Code	Link
Inhibition of NO production in macrophage	SF2425 (Sulfate)	FNK-17577
Antitumor effect/Cytotoxicity/Anti-angiogenesis	Bactobolin A (Hydrochloride)	FNK-08465
	Clazamycin A (Hydrochloride)	FNK-16715
	Lavendamycin	FNK-16734
	MC-1	FNK-16479
Immunomodulation/Immunosuppressant effect	Bactobolamine	FNK-15160
Immunomodulation/Immunosuppressant effect	Conagenin	FNK-16969
Siderophore	Foroxymithine	FNK-16968
Antihypertensive effect	Oudenone (Potassium Salt)	FNK-16640
Infectious Disease Prevention	Compound Name	Product Code	Link
Antibacterial activity/Antifungal activity	SF2425 (Sulfate)	FNK-17577
Antibacterial activity/Antifungal activity	Lavendamycin	FNK-16734
Antimalarial	Aplasmomycin (Sodium Salt)	FNK-17683
Bacterial proteins/Inhibition of DNA synthesis	Actinobolin (Sulfate)	FNK-15172
Bacterial proteins/Inhibition of DNA synthesis	Clazamycin A (Hydrochloride)	FNK-16715

Natural macrocyclic compounds from microorganisms:

Structural classification	Compound Name	Property / Biological activity	Link
Bacterial proteins/Inhibition of DNA synthesis	Aplasmomycin (Sodium Salt)	Aplasmomycin A Inhibited the growth of gram-positive bacteria including mycobacteria and showed an antimalarial activity in mice infected with Plasmodium berghei.
Bacterial proteins/Inhibition of DNA synthesis	Migrastatin	Migrastatin inhibited metastasis of human esophageal cancer cells and anchorage-independent growth of human small cell lung carcinoma cells.
Macrolactams	Bisucaberin	Bisucaberin is a siderophore with iron-affinity and induced concentration dependent macrophage-mediated tumor cell lysis.
Cyclic peptides	Bottromycin A2	Bottromycin A2 showed growth inhibitory activity against gram-positive bacteria, MRSA (Methicillin-resistant Staphylococcus aureus), and VRE (Vancomycin-resistant Enterococci).
	Iturin A-2	Iturin A-2 showed the control of damping-off of tomato (a seedling disease) and cytotoxicity to human breast cancer cell line BT-474.
	Plipastatin A1	Plipastatin A1 inhibited phospholipase A2 and induced ISR (induced-systemic-resistance).
	Phepropeptin A	Phepropeptin A inhibited proteasomal chymotrypsin-like activity.
	Phepropeptin B	Phepropeptin B inhibited proteasomal chymotrypsin-like activity.
	Phepropeptin C	Phepropeptin C inhibited proteasomal chymotrypsin-like activity.	Current Link
	Phepropeptin D	Phepropeptin D inhibited proteasomal chymotrypsin-like activity.
Cycloalkenes	Rubratoxin A	Rubratoxin A inhibited protein phosphatase 2A (PP2A) in a competitive manner.