Lactacystin, 5 mg
Product#: FNK-BLK-0460-5mg
$792.62
Availability:
Ships in 1-2 Weeks
Lactacystin
Cat No: FNK-BLK-0460-5mg
Product ID and Size
| Cat No. | Description | Size | Link |
| FNK-BLK-0460-100ug | Lactacystin | 100μg |  |
| FNK-BLK-0460-500ug | Lactacystin | 500μg | |
| FNK-BLK-0460-1mg | Lactacystin | 1mg | |
| FNK-BLK-0460-5mg | Lactacystin | 5mg | |
Description
Biological activity: 1) Lactacystin inhibits cell cycle progression and induces neurite outgrowth in Neuro 2a cells. 2) Inhibits proteasome activity. Proteasome exhibits three protease activities of the tree, Lactacystin inhibits chymotrypsin-like activity most potently, followed by trypsin-like activity, but its inhibitory activity against peptidylglutamylpeptide hydrolytic activity is relatively weak.
Origin: Streptomyces lactacystinnaeus OM-6519
CAS Registry Number: 133343-34-7
Appearance: White powder
Molecular Formula/ Weight: C15H24N2O7S=376.13
Purity: >98.0% by HPLC
Solubility: Sol. in DMSO, MeOH, EtOH, water
Handling and Storage: Store at -20℃.
References:
- S. Omura, et al., J. Antibiot., 44, 113 (1991).
- S. Omura, et al., J. Antibiot., 44, 117 (1991).
- H. Tomoda, et al., Yakugaku Zasshi, 120, 935 (2000).
- M. Katagiri, et al., J. Antibiot., 48, 344 (1995).
- G. Fenteany, et al., Science, 268, 726 (1995).
- K. Tanaka, et al., J. Leukocyte Biol., 56, 571 (1994).
- M. Groll, et al., Nature, 386, 463 (1997).
- L. R. Dick, et al., J. Biol. Chem., 272, 182 (1997).
- E. J. Corey, et al., Chem. Pharm. Bull., 47, 1 (1990).
- A. Nakagawa, et al., Tetrahedron Lett., 35, 5009 (1994).
- S. Takahashi, et al., J. Antibiot., 48, 1015 (1995).
- T. Sunazuka, et al., J. Am. Chem. Soc., 115, 5302 (1993).
- T. Sunazuka, et al., Tetrahedron Lett., 34 4447 (1993).
- T. Nagamitsu, et al., J. Am. Chem. Soc., 118, 3584 (1996).
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