Clazamycin A(hydrochloride), Antibacterial, Antitumor
Product#: FNK-16715
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Clazamycin A(hydrochloride), Antibacterial, Antitumor
Specifications
Code No. : FNK-16715
CAS# : 71743-75-4
Size: 1 mg
Molecular Formula : C7H9ClN2O HCl
Molecular Weight : 209.070
Source : Streptomyces sp.
Supplied as : Powder
Purity : >95 % (HPLC)
Long Term Storage : at -20 °C , under argon atmosphere
Solubility : Soluble in H2O and DMSO
Slightly soluble in MeOH
Application Notes
Clazamycins A and B were isolated from culture filtrates of Streptomyces No. MF990-BF4 and the structure of clazamycin A was determined by X-ray diffraction methods.1-2) Clazamycins exist in aqueous solution as an epimeric mixture of clazamycins A and B.1-3) Clazamycins had weak antibacterial activity and inhibited leukemia L-1210 in mice.1) Note: Clazamycin B is contained (< 5%) as an equilibrium isomer of clazamycin A. The ratio of
clazamycin A and B is pH dependent.1)It is recommended to resolve into acidic solution (recommended pH is < 3) due to avoid equilibration and decomposition. The stock solution shouldbe stored at 4°C or lower, and should be used within a couple of days.
References
1) New antibiotics, clazamycins A and B. Horiuchi Y, et al. J Antibiot. 1979 32(7) 762-764.
2) Crystal and molecular structure of clazamycin A. Nakamura H, et al. J Antibiot. 1979 32(7) 765-767.
3) Studies on the pyrrolizidine antitumor agent, clazamycin: interconversion of clazamycins A and B. Buechter D D. et al, J
Nat Prod. 1987 50(3) 360-367.
Description
Clazamycin A is an antibiotic and microbial metabolite originally isolated from Streptomyces bacteria[2]. It is a pyrrolizidine compound with the molecular formula C7H9ClN2O[1]. This organic compound has demonstrated activity against various bacteria, including Staphylococcus species[2].
In addition to its antibacterial properties, Clazamycin A has also been studied for its potential antitumor effects[5]. Research has shown that it exists in aqueous solution as one of two epimers, alongside Clazamycin B[5].
Clazamycin A is primarily used as a research compound in life sciences[4]. It is available commercially in various forms, including as a hydrochloride salt[2][3]. The compound's unique structure and biological activities make it an interesting subject for further investigation in both antimicrobial and cancer research fields.
Citations:
[1] https://pubchem.ncbi.nlm.nih.gov/compound/Clazamycin-A
[2] https://www.caymanchem.com/product/40224/helping-make-research-possible
[3] https://www.diagnocine.com/Product/Clazamycin-Ahydrochloride-Antibacterial-Antitumor/94009
[4] https://www.targetmol.com/compound/clazamycin_a
[5] https://pubs.acs.org/doi/pdf/10.1021/np50051a004
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