O-Carbamyl-D-serine (Inhibitor of bacterial cell wall synthesis

                                                                            


Cat.No: FNK-20324

Size: 10 mg

Storage: -20℃ 

Molecular Weight: 148.118

Purity: >98% (qNMR)

CAS#: 3819-76-9

Molecular Formula: C₄H₈N₂O₄

Source: Streptomyces sp.

Appearance: Powder

Solubility: Soluble in H₂O, Sightly soluble in MeOH


The chemical structure was confirmed by NMR and HRMS.
 

Application

O-carbamyl-D-serine was isolated from the fermentation broth of streptomyces.^1,2) It had weak activity against Gram-positive bacteria and inhibited bacterial cell wall biosynthesis as a D-alanine antagonist.^2,3) It showed synergistic activity with D-4-amino-3-isoxazolidone and rescued 30% of mice from the intraperitoneal infection of S. aureus.³⁾

References

1) Sur un deriv? de la seine, la O-carbamyl-D-serine, produit par un streptomyces. Hagemann G, et al. Biochemica et Biophysica Acta. 1955 17 240-243.

2) A streptomyces producing O-carbamyl-D-serine. Okami Y, et al. J Antibiot.Ser. A 1962 15(3) 147-150.

3) Mechanism of action of O-carbamyl-D-serine. Tanaka N, et al. J Antibiot.Ser. A 1963 16(6) 217-221.