Anti-Mouse ARHGEF2 (KIAA0651) Polyclonal Antibody, Rabbit
Product#: FNK-MK06510910
$495.39
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Anti-Mouse ARHGEF2 (KIAA0651) Polyclonal Antibody, Rabbit
General information
| Cat. No. | ：FNK-MK06510910 |
| Quantity | ：50 µg (250 µL) |
| Gene | ：mouse Rho/Rac guanine nucleotide exchange factor 2 (mARHGEF2, mKIAA0651) |
| Immunogen | ：GX0005 (GST-fusion protein, 209 amino acids) SRANSRDGEAGRAAVASVTPEKQATELALLQRQHTLLQEELRRCQRLGEERATEAGSLEARLR ESEQARALLEREAEEIRRQLAALGQNEPLPAEAPWARRPLDPRRRSLPAGDALYLSFNPPQPS RGHDRLDLPVTVRSLHRPFDDREAQELGSPEDRLQDSSDPDTGSEEEVSSRLSPPHSPRDFT RMQDIPEETESRDGEPTASES |
| Format | ：Affinity Purified Rabbit IgG |
| Constitution | ：PBS containing with 50% glycerol and 0.02% of NaN3 |
| Antigen Species | ：Mouse |
| Host Species | ：Rabbit |
| Label | ：Unlabeled |
| Cross Reactivity | ：Human/ Mouse |
| Application | ：Western blotting (1 : 1,000), Other applications have not been tested. |
| Specificity |
：Specific to recombinant protein GX0005. This antibody detects mARHGEF2 protein. It also recognizes
human ARHGEF2 protein. Details are shown in the InGaP database. Other species have not been tested. |
| Storage | ：Store at -20°C. Avoid freeze-thaw cycles. |
Antigen Characterization
| Type | ：Guanine nucleotide exchange factor protein |
| Application | ：Western Blot, Immunoprecipitation, Immunofluorescence |
| Species | ：Human, Mouse, Rat |
| Recombinant | ：Yes |
ARHGEF2 in the Cell
- Functions as a guanine nucleotide exchange factor for Rho GTPases, particularly RhoA
- Stimulates the conversion of RhoA-GDP to RhoA-GTP, activating it
- Regulates cytoskeleton organization
- Plays a role in cell division
- Involved in signal transduction
- Couples microtubule depolarization with Rho-mediated actin stress fiber formation
- Participates in cell contraction
- Activates signaling pathways in response to inflammatory, mitogenic, and morphogenic stimuli
ARHGEF2 in the Human Body
- Contributes to various physiological processes
- Involved in immune cell function:
- Regulates migration and inflammatory responses of dendritic cells and T lymphocytes
- Crucial for Th1/Th17 differentiation in T cells
- Plays a role in the nervous system:
- Regulates neural differentiation in the cerebral cortex
- Influences mRNA m6A-methylation of specific genes in neural development
- Associated with tumor progression in certain cancers:
- Implicated in hepatocellular carcinoma
- Involved in high-grade melanomas
- Potential target for therapeutic interventions in:
- Inflammatory diseases
- Cancer treatment
References
- Okazaki,N. et al.: DNA Res., 10(1), 35 (2003).
- Whitehead,I. et al.: J. Biol. Chem. 270 (31), 18388 (1995)
Aliases for ARHGEF2 Gene
- Rho/Rac Guanine Nucleotide Exchange Factor 2 2 3 5
- Rho/Rac Guanine Nucleotide Exchange Factor (GEF) 2 2 2 3
- GEF-H1 2 3 4
- LFP40 2 3 4
- Rho Guanine Nucleotide Exchange Factor 2 3 4
- Proliferating Cell Nucleolar Antigen P40 3 4
- Guanine Nucleotide Exchange Factor H1 3 4
- Microtubule-Regulated Rho-GEF 3 4
- KIAA0651 2 4
- GEFH1 2 3
- Lfc 2 3
- P40 2 3
- ARHGEF2 5
- NEDMHM 3
- GEF 3
