Anti-MAdCAM1 Rabbit Polyclonal Antibody (IHC/IF)
Product#: SB-GB111006
$779.20
Availability:
Ships in 1-2 Weeks
Anti-MAdCAM1 Rabbit Polyclonal Antibody (IHC/IF)
General information
| Cat. No. | ：SB-GB111006 |
| Size | ：100 uL |
| Protein full name | ：Mucosal addressin cell adhesion molecule 1 |
| Synonym | ：MAdCAM-1, mMAdCAM-1, Madcam1, Addressin mucosal, hMAdCAM 1, MACAM1, Mucosal vascular addressin cell adhesion molecule 1 |
| Immunogen | ：KLH conjugated Synthetic peptide corresponding to Mouse MAdCAM1 |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Subcellular location | ：Cell Membrane |
| Uniprot ID | ：Q61826, O70540 |
| Long Term Storage | ：-20 ℃ or below |
| Shipping Condition | ：Dry Ice |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| IHC/IF | Human, Mouse, Rat | 1: 500-1: 3000 |
appendix, colon, lung+LPS, pancreas+LPS, pancreatic, small intestine |
Description
MAdCAM-1 is an immunoglobulin (Ig) cell adhesion molecule family member. MAdCAM-1 is involved in lymphocyte homing to mucosal sites and is expressed on high endothelial venules (HEV) of both mesenteric lymph nodes and Peyer's patches. It has also been found to be expressed on sinus-lining cells of the spleen. The integrin, alpha 4 beta 7, has been shown to function as the MAdCAM-1 receptor. The Ig domains of MAdCAM-1 have been found to be critical to alpha 4 beta 7 binding. The mucin domain has been shown to have activity in L-Selectin binding.
 |
Immunohistochemistry of paraffin embedded mouse pancreatic using MADCAM1 (GB111006) at dilution of 1:1700 (400x lens) |
 |
Immunohistochemistry of paraffin embedded mouse small intestine using MADCAM1 (GB111006) at dilution of 1:1700 (400x lens) |
 |
Immunohistochemistry of paraffin embedded mouse small intestine using MADCAM1 (GB111006) at dilution of 1:1800 (400x lens)
|
 |
Immunohistochemistry of paraffin embedded rat colon using MADCAM1 (GB111006) at dilution of 1:1800 (400x lens)
|
 |
Immunohistochemistry of paraffin embedded rat colon using MADCAM1 (GB111006) at dilution of 1:3400 (400x lens)
|
 |
Immunohistochemistry of paraffin embedded rat pancreas+LPS using MADCAM1 (GB111006) at dilution of 1:1800 (400x lens)
|
 |
Immunohistochemistry of paraffin embedded rat pancreas+LPS using MADCAM1 (GB111006) at dilution of 1:3400 (400x lens)
|
 |
Immunohistochemistry of paraffin embedded rat pancreatic using MADCAM1 (GB111006) at dilution of 1:1700 (400x lens)
|
 |
Immunohistochemistry of paraffin embedded rat pancreatic using MADCAM1 (GB111006) at dilution of 1:1800 (400x lens)
|
 |
Immunofluorescence of paraffin embedded human appendix using MADCAM1 (GB111006) at dilution of 1:1800 (400x lens)
|
 |
Immunofluorescence of paraffin embedded human colon using MADCAM1 (GB111006) at dilution of 1:1800 (400x lens)
|
 |
Immunofluorescence of paraffin embedded human colon using MADCAM1 (GB111006) at dilution of 1:1800 (400x lens)
|
 |
Immunofluorescence of paraffin embedded mouse lung+LPS using MADCAM1 (GB111006) at dilution of 1:1800 (400x lens)
|
Antigen Characterization
- Type: Primary
- Application: ELISA,Western Blot (WB),Immunohistochemistry (IHC),Flow Cytometry (FCM),Immunoprecipitation
- Species: Human,Mouse
- Recombinant: Yes
Human Diseases
- Ulcerative Colitis (UC): MAdCAM-1 is upregulated in UC, contributing to leukocyte trafficking and inflammation in the gut mucosa. Monoclonal antibodies targeting MAdCAM-1, such as ontamalimab, have shown efficacy in clinical trials for UC treatment.
- Crohn's Disease: Similar to UC, MAdCAM-1 plays a role in the pathogenesis of Crohn's disease by mediating leukocyte adhesion and migration to inflamed intestinal tissues.
- Multiple Sclerosis (MS): MAdCAM-1 may also be involved in MS due to its expression in the central nervous system during inflammatory responses
Cellular Signaling Pathways
- Integrin Signaling: MAdCAM-1 interacts with the α4β7 integrin on leukocytes, facilitating their migration to mucosal tissues. This interaction is crucial for immune surveillance and response during inflammation.
- Cytokine Signaling: MAdCAM-1 expression can be influenced by cytokines such as TNF-α and IL-6, which are often elevated during inflammatory conditions, leading to increased leukocyte recruitment.
- Endothelial Cell Activation: MAdCAM-1 is expressed on endothelial cells in high endothelial venules, where it plays a role in the recruitment of lymphocytes during immune responses
Aliases for MADCAM1 Gene
References
- L, Jiang, et al. “Characterization of Leptin Receptor+ Stromal Cells in Lymph Node.” MAdCAM1 Monoclonal Antibody (MECA-367), Functional Grade (16-5997-85), www.thermofisher.com/antibody/product/MAdCAM1-Antibody-clone-MECA-367-Monoclonal/16-5997-85.
- Reinisch, Walter, et al. “Long-Term Safety and Efficacy of the Anti-Madcam-1 Monoclonal Antibody Ontamalimab [Shp647] for the Treatment of Ulcerative Colitis: The Open-Label Study Turandot II.” Journal of Crohn’s & Colitis, U.S. National Library of Medicine, 22 June 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8218706/.
- Human MAdCAM-1 Antibody.” Www.Rndsystems.Com, www.rndsystems.com/products/human-madcam-1-antibody-683715_mab6056. Accessed 27 Sept. 2024.
- gaia12, et al. “MAdCAM-1 Antibody (H-3): SCBT - Santa Cruz Biotechnology.” SCBT, 3 Feb. 2021, www.scbt.com/p/madcam-1-antibody-h-3.
- Anti Human Madcam-1 Antibody, Clone 17F5: Bio-Rad.” Bio, www.bio-rad-antibodies.com/monoclonal/human-madcam-1-antibody-17f5-mca2321.html.
Recently Viewed
pH35CG Vector
$990.77
Campesterol
$462.38
BMPro Medium
$151.65
OptiPreserv
$1.00
L-Sorbose, ≧99%
$127.91
Forphenicine
$598.00