Forphenicine
Product#: FNK-09636
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Forphenicine(Inhibitor for alkaline phosphatase)
Specifications
Code No.: FNK-09636
CAS#: 57784-96-0
Molecular Formula: C9H9NO4
Molecular Weight: 195.174
Source: Streptomycesfulvoviridisvar. acarbodicus MC974-A5
Appearance: Pale yellow crystals
Purity: > 90%(HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in diluted acetic acid and H2Oand diluted aqueous HCl Insoluble in MeOH, Benzene, Pyridine and DMSO.
CAS#: 57784-96-0
Molecular Formula: C9H9NO4
Molecular Weight: 195.174
Source: Streptomycesfulvoviridisvar. acarbodicus MC974-A5
Appearance: Pale yellow crystals
Purity: > 90%(HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in diluted acetic acid and H2Oand diluted aqueous HCl Insoluble in MeOH, Benzene, Pyridine and DMSO.
Application Notes
Forphenicine is isolated from fermentation broth of Streptomyces fulvoviridis var. acarbodicus MC974-A5.1,2 Forphenicine shows potent inhibition against alkaline phosphatase prepared from chicken intestine (IC50 value is 0.036 μg/mL) and slightly inhibits the enzymes prepared from calf intestine, liver and Escherichia coli. The type of inhibition of chicken intestine enzyme by forphenicine is uncompetitive with p-nitrophenyl phosphate and its Ki value is 1.64×10-7M.1 Forphenicine enhances delayed-type hypersensitivity (DTH) and increase the number of antibody-forming in mice. Forphenicinol, orally administrable forphenicine derivative, has been studied.3,4
Role in Human Disease
- Immunomodulatory Effects: In animal studies, forphenicine has been shown to enhance delayed-type hypersensitivity and increase antibody production capacity. This suggests potential applications in modulating immune responses.
- Anti-Tumor Activity: Forphenicine has demonstrated inhibition against Gardner lymphosarcoma in certain studies, indicating possible anti-tumor properties.
Cell Signalling Pathway
- Alkaline Phosphatase Inhibition: By inhibiting alkaline phosphatase, forphenicine can potentially affect various signaling pathways that rely on phosphorylation and dephosphorylation cycles. These cycles are essential for activating or deactivating proteins involved in signal transduction.
- Impact on Phosphorylation: Since phosphorylation is a key post-translational modification that regulates numerous cellular processes, including metabolism, cell growth, and apoptosis, the inhibition of enzymes like alkaline phosphatase can have downstream effects on these processes.
- Forphenicine, an inhibitor of alkaline phosphatase produced by actinomycetes. Aoyagi T, et al. J Antibiot. 1978 31(3) 244-246.
- The structure of forphenicine. Yamamoto T, et al. J Antibiot. 1978 31(5) 483-484.
- Synthesis of forphenicinol and forphenicine. Morishima H, et al. J Antibiot. 1982 35(11) 1500-1506.
- Studies on effects of forphenicinol on immune responses. Ishizuka M, et al. J Antibiot. 1982 35(8) 1042-1048
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