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Anti Human LXR alpha Ligand Binding Domain mouse monoclonal antibody (PPZ0412)

Product#: FNK-PP-PPZ0412-00

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Anti Human LXR alpha Ligand Binding Domain mouse monoclonal antibody (PPZ0412)
LXR beta: Liver X Receptor beta

General information

Cat. No.	：FNK-PP-PPZ0412-00
Size	：100 ul
Antigen Species	：Human
Host Species	：Mouse
Cross Reactivity	：Human/ Mouse/ Rat
Purification	：Ammonium sulfate fractionation.
Clone No	：PPZ0412
Lot.	：A-2
Concentration	：1 mg/mL
Ig Class	：G2a
Nomenclature	：NR1H3
Application	：ELISA : 0.2 ug/mL ：Western Blot : 1 ug/mL ：Immunohistochemistry : 20-40 ug/mL
Specificity	：This antibody specifically recognizes human LXR alpha and cross reacts with mouse and rat LXR alpha. This antibody does not recognize human LXR beta.
Storage	：Store at 2 - 8 ºC up to one month. For long-term storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in a frost-free freezer is not recommended.
Form	：Physiological saline with 0.1% NaN₃ as a preservative.
Genbank	：U22662

Description

Liver X receptor alpha (LXRa, RLD-1; NR1H3) is a member of orphan nuclear receptor. LXRa activator is the naturally occurring compound 22(R)- hydroxycholesterol (22(R)-HC), 20(S)HC, 24-HC, 25- HC, 7a-HC. LXRa is expressed in the liver, kidney and spleen. LXRa has important role in regulating cholesterol metabolism. It is believed that LXR specific agonist may have important medical applications in the regulation of cholesterol homeostasis. LXRa forms heterodimer with RXR.

Origin

Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with E.coli-expressed recombinant human LXR alpha (164-447 aa).

Notes

Sodium azide may react with lead and copper plumbing to form explosive metal azides. Flush with large amounts of water during disposal.

Reference