Thrombin Time (TT) Reagent

Catalog No.: DCP-TTR

Size:  20 mL
Sterile:  Filtered 0.1-micron membrane TWICE, 0.04-micron membrane TWICE

Storage:  -20°C, in dark container
Shelf Life:  Unopened: 24 months
                   Opened: 4 weeks in 2–8°C
                   *Use before the expiry date given on the product label.

pH:   7.35-7.45

Description:
A reagent fully compatible (not exclusive) with the Blood Coagulation Analyzer (Catalog No.: DCBio-SACA) [Link]

A standardized, lyophilized coagulation reagent containing highly purified bovine thrombin, formulated for the quantitative determination of thrombin time (TT) — also known as thrombin clotting time (TCT) — in human citrated plasma. Upon reconstitution and addition to a pre-warmed plasma specimen, thrombin directly converts fibrinogen to fibrin, bypassing all upstream coagulation factors and isolating the terminal step of the common pathway. The clotting time recorded (in seconds) reflects the quantity, quality, and functional integrity of fibrinogen, as well as the presence of thrombin inhibitors such as heparin or direct thrombin inhibitors (DTIs).

The thrombin time assay interrogates the final and most direct step of the coagulation cascade: the thrombin-mediated conversion of soluble fibrinogen to insoluble fibrin. Unlike the PT and APTT, which activate the cascade upstream and require the sequential function of multiple coagulation factors, the TT test bypasses the entire intrinsic, extrinsic, and common pathways — adding a known, standardized concentration of thrombin (Factor IIa) directly to the plasma sample

Supplied as a lyophilized frozen liquid ready for use.
 

Composition:

Ingredients

Bovine Thrombin (α-Thrombin)

BSA (fatty-acid free)

Imidazole (buffer vehicle)

Sodium Chloride

Glycerol (cryoprotectant)

Ultrapure Water

* All DiagnoCine Precision Sterile filtered-sterilized with 40 nanometer. Thus, mycoplasma contamination is prevented. The smallest size mycoplasma type can be about 0.2 microns.

* This product is manufactured under ISO 13485-certified and CE-approved facilities (Suppliers of DiagnoCine Precision). All final packaging, quality assurance, and testing are done at the DiagnoCine R&D and Quality Testing Center.  All specific customization requests and assembly were accomplished at DiagnoCine Precision in Totowa, New Jersey, USA