PIPA (Py-Im-Polyamide) is a gene expression control reagent, consisting of all non-proteinogenic amino acids, such as N-methylpyrrole (Py), N-methylimidazole (Im), β-Alanine (βAla) and γ-aminobutyric acid (γAbu).
PIPA can bind to specific nucleotide sequences in the minor groove of double-helical DNA with high affinity and specificity, suggesting that PIPA blocks binding of transcription factors inhibiting gene expression, thus PIPA can be used for gene-control.
Features
Alternative gene silencer other than siRNA or PNA
Stable in cells or bodies because of nuclease resistance
Specifically binds to the target double strand DNA
Flexible Design against any gene
No-toxicities have been found in animal experiments