PLEASE INQUIRE! PIPA for Human TGF-β1 (1mg)
PIPA for Human TGF-β1
Cat. No. HPTB02
Size 100ug /1mg
| Product No. | Size | Link |
| FNK-HPTB02-100 ug | 100 µg |  |
| FNK-HPTB02-1 mg | 1 mg | |
Description
PIPA (Py-Im-Polyamide) is a gene expression control reagent, consisting of all non-proteinogenic amino acids, such as N-methylpyrrole (Py), N-methylimidazole (Im), β-Alanine (βAla) and γ-aminobutyric acid (γAbu).
PIPA can bind to specific nucleotide sequences in the minor groove of double-helical DNA with high affinity and specificity, suggesting that PIPA blocks binding of transcription factors inhibiting gene expression, thus PIPA can be used for gene-control.
Features
- Alternative gene silencer other than siRNA or PNA
- Stable in cells or bodies because of nuclease resistance
- Specifically binds to the target double strand DNA
- Flexible Design against any gene
- No-toxicities have been found in animal experiments
- Form : Freeze dried powder
- No additives
|
Code |
Structure (C-terminal amide) |
Mol. Weight |
Target Gene |
Reference |
|
HPTB01 |
Ac-Im-Py-Py-βAla-Im-Py-Py-gAbu-PyPy-Py-βAla-Py-Py-βAla-Dp |
1787.9 |
Human TGF-β1 |
1 |
|
HPTB02 |
Ac-Im-Im-βAla-Im-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp |
1667.75 |
Human TGF-β1 |
1 |
|
HPTB03 |
Ac-Im-Py-Im-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Py-Py-Py-βAla-Dp |
1912 |
Human TGF-β1 |
1 |
|
HPTB04 |
Ac-Py-Py-βAla-Py-Im-Py-gAbu-Py-Py-Py-βAla-Im-Py-βAla-Dp |
1665.78 |
Rat TGF-β1 |
2 |
|
HPLH05 |
Ac-Im-Py-Im-βAla-Py-Py-Im-gAbu-Py-Py-Py-βAla-Py-Py-Py-βAla-Dp |
1911.01 |
Human LOX-1 |
3 |
|
HPLR06 |
Ac-Py-Py-βAla-Py-Py-Im-gAbu-Py-Im-Im-βAla-Py-Im-βAla-Dp |
1667.75 |
Rat LOX-1 |
4 |
|
HPCT07 |
Ac-Im-Py-Py-βAla-Py-Py-Py-gAbu-Im-Py-Im-βAla-Im-Py-Py-βAla-Dp |
1912 |
Human CTGF |
5 |
|
HPTE08 |
Ac-Py-Im-βAla-Im-Im-Im-gAbu-Im-Py-Py-βAla-Py-Py-βAla-Dp |
1668.74 |
TMPRSS2-ERG |
6* |
|
HPTE09 |
Ac-Py-Im-βAla-Im-Im-Im-gAbu-Py-Py-Py-βAla-Py-Py-βAla-Dp |
1667.75 |
TMPRSS2-ERG |
6* |
* Published patent
Gene Control Reagent : PIPA
Alternative gene silencer other than siRNA or PNA
PIPA (Py-Im-Polyamide)
Reference
- Igarashi, J. et. al., PLoS One. 2015,10, e0125295.
- Matsuda, H. et. al., Kidney Int. 2011, 79, 46-56.
- Kamei, T. et. al., J. Biomed. Biotechnol., 2012, 2102:715928.
- Yao, E. H. et. al., Hypertension, 2008, 52, 86-92.
- Wan, J. X.et. al., Biol. Pharm. Bull. 2011, 34, 1572-1577.
- Obinata, D. et. al., Cancer Sci., 2014, 105, 1272-1278.
- P. B. Dervan et. al., Nature (1998) 391 468-471
- P. B. Dervan and R. W. Burli, Current Opinion in Chemical Biology 3 (1999) 688-693
- P. B. Dervan, Bioorganic & Medicinal Chemistry 9 (2001) 2215-2235.
