1. over-expression of NOV in pancreatic cancer cells promoted cell proliferation and migration, while knock down the expression of NOV impaired the tumorigenecity of pancreatic cancer cells in vitro and in vivo PMID: 24258112
2. CCN3 may play an important role in cervical carcinogenesis and therefore may have potential as a biomarker for prognosis and as a therapeutic target in cervical cancer. PMID: 24431313
3. NOV may promote carcinogenesis via promotion of EMT and association with increased mTOR activity PMID: 24719190
4. Overexpression of CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment. PMID: 24721786
5. our results argue that MZF-1 regulates the CTGF and NOV genes in the hematopoietic compartment, and may be involved in their respective functions in the stroma. PMID: 25899830
6. Results revealed that NOV regulates the tumor growth of osteosarcoma cells through activation of the MAPK signaling pathway and promotes osteosarcoma cell migration in vitro. PMID: 26238193
7. NOV expression was highly increased in biopsies of patients with tubulointerstitial nephritis. PMID: 26367310
8. Studies indicate that the CYR61 CTGF NOV matricellular proteins (CCN family of proteins) comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6 and have been identified in various types of cancer. PMID: 26498181
9. Reduced levels of CCN1 and CCN3, as found in early-onset preeclampsia, could contribute to a shift from invasive to proliferative extravillous trophoblasts and may explain their shallow invasion properties in this disease. PMID: 26744771
10. CCN3 (Nov) and CCN5 (WISP2) are novel substrates of MMP14. PMID: 27471094
11. down-regulation of Lamin B1 and up-regulation of Nephroblastoma overexpressed (NOV) are at least partially responsible for the inhibitory effect of Huaier on the proliferative and invasive capacity of SKHEP-1 cells PMID: 27503760
12. The present study aimed to examine the clinical relevance of NOV along with CYR61 and CTGF in gastric cancer by analysing their transcript levels...the expression of NOV and CYR61 was increased in gastric cancer. The elevated expression of CYR61 was associated with poorer survival. NOV promoted proliferation and invasion of gastric cancer cells PMID: 27633176
13. our findings establish CCN3 as a pivotal regulator of androgen receptor (AR) signaling and prostate cancer progression and suggest a functional intersection between EZH2 and AR signaling in castration-resistant prostate cancer PMID: 27815387
14. NOV is down-regulated in CRC tumours which is associated with disease progression. PMID: 28412738
15. NOV is a novel biomarker of the presence and severity of OSA and a potential marker of future cardiovascular and metabolic disease in OSA patients. PMID: 28862983
16. Taken together, our results suggest that palmitoylation by ZDHHC22 at C241 in the CCN3 TSP1 domain may be required for the secretion of CCN3. Aberrant palmitoylation induces intracellular accumulation of CCN3, inhibiting neuronal axon growth. PMID: 29287726
17. This is the first evidence of downregulation of TGFbeta1-mediated activation of a Smad1/5/8 signalling pathway by CCN3 in human podocytes and in any cell type. PMID: 29506624
18. A significant reduction of CCN3 expression was observed in lesioned skin compared to non-lesioned skin in vitiligo patients. PMID: 29998862

HGNC: 7885

OMIM: 164958

KEGG: hsa:4856

STRING: 9606.ENSP00000259526

UniGene: Hs.235935