Benastatin A
Product#: FNK-00379
$598.00
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Benastatin A
Specifications
Code No.: FNK-00379
Size: 1mg
CAS#: 138968-85-1
Molecular Formula: C30H28O7
Molecular Weight: 500.547
Source: Streptomyces sp. MI384-DF12
Appearance: Brownish-yellow powder
Purity: > 90%(HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in DMSO. Poorly soluble in MeOH, CHCl3. Insoluble in H2O.
Application Notes
Size: 1mg
CAS#: 138968-85-1
Molecular Formula: C30H28O7
Molecular Weight: 500.547
Source: Streptomyces sp. MI384-DF12
Appearance: Brownish-yellow powder
Purity: > 90%(HPLC)
Long Term Storage: at -20 °C
Solubility: Soluble in DMSO. Poorly soluble in MeOH, CHCl3. Insoluble in H2O.
Benastatin A is isolated from the culture broth of Streptomyces sp. MI384-DF12 as an inhibitor of glutathione S-transferase (GST).1,2 The inhibition of benastatin A against GST is competitive with 3,4-dichloronitrobenzene (Ki: 5.0 × 10-6 M), and noncompetitive with glutathione (Ki: 3.5 × 10-6 M). Benastatin A has activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).
References
- Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. Aoyagi T. et al. J Antibiot. 1992 45(9) 1385-1390.
- Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. II. Structure determination of benastatins A and B. Aoyama T. et al. J Antibiot. 1992 45(9) 1391-
1396.
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