Belactin A Serine Carboxypeptidase Inhibitor
Product#: FNK-17736
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Belactin A Serine Carboxypeptidase Inhibitor
Cat No.: FNK-17736
Description:A natural product with a β-lactone ring that specifically inhibits serine carboxypeptidase Y (CP-Y).
Application Notes:
Belactin A was isolated from culture filtrate of Saccharopolyspora sp. MK19-42F6. Its structure was
determined by various spectral analyses. Belactin A had specific inhibitory activity toward
carboxypeptidase Y (IC50 = 0.18 μg/ml) compared with other β-lactone-containing inhibitors, such as
ebelactones A and B and esterastin.
Specifications:
Molecular Formula : C17H21ClN2O4
Molecular Weight : 352.815
Source : Saccharopolyspora sp.
Appearance : Powder
Purity : > 98% (HPLC)
Long Term Storage : at – 20 °C
Solubility : Soluble in MeOH, DMSO
Storage conditions: -20℃
References:
1) Belactins A and B, new serine carboxypeptidase inhibitors produced by actinomycete. I. taxonomy, production, isolation
and biological activities. Murakami S, et al. J. Enzyme Inhibition. 1995 9 263-275.
2) Belactins A and B, new serine carboxypeptidase inhibitors produced by actinomycete. II. Physico-chemical properties,
structure determination and enzymatic inhibitory activities compared with other β-lactone containing inhibitors. Murakami
S, et al. J. Enzyme Inhibition. 1995 9 277-284.
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|---|---|---|---|---|---|---|---|
| Serine carboxypeptidase inhibitor | Belactin A | FNK-17736 | Current link | ||||
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| Biological Activity on Cells and Organisms | Compound Name | Product Code | Link | ||||
| Inhibition of NO production in macrophage | SF2425 (Sulfate) | FNK-17577 | |
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| Antitumor effect/Cytotoxicity/Anti-angiogenesis | Bactobolin A (Hydrochloride) | FNK-08465 | |
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| Clazamycin A (Hydrochloride) | FNK-16715 | |
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| Lavendamycin | FNK-16734 | |
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| MC-1 | FNK-16479 | |
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| Immunomodulation/Immunosuppressant effect | Bactobolamine | FNK-15160 | |
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| Conagenin | FNK-16969 | |
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| Siderophore | Foroxymithine | FNK-16968 | |
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| Antihypertensive effect | Oudenone (Potassium Salt) | FNK-16640 | |
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| Infectious Disease Prevention | Compound Name | Product Code | Link | ||||
| Antibacterial activity/Antifungal activity | SF2425 (Sulfate) | FNK-17577 | |
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| Lavendamycin | FNK-16734 | |
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| Antimalarial | Aplasmomycin (Sodium Salt) | FNK-17683 | |
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| Bacterial proteins/Inhibition of DNA synthesis | Actinobolin (Sulfate) | FNK-15172 | |
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| Clazamycin A (Hydrochloride) | FNK-16715 | |
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