Anti-WEE2 Rabbit Polyclonal Antibody
Anti-WEE2 Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB113669 |
| Size | ：100 uL |
| Protein full name | ：Wee1-like protein kinase 2 |
| Synonym | ：WEE1 homolog 2 (S. pombe), Wee1 like protein kinase 1B, WEE1B, Wee1B kinase, WEE2 |
| Immunogen | ：KLH conjugated Synthetic peptide corresponding to Mouse WEE2 |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Predicted MW. | ：62 kDa |
| Observed MW. | ：62 kDa |
| Uniprot ID | ：P0C1S8 |
| Storage | ：Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| WB | Human | 1: 300-1: 600 |
Jurkat, A-431, U-20S, HUVEC |
Description
WEE2, also named as WEE1B, belongs to the protein kinase superfamily. Ser/Thr protein kinase family and WEE1 subfamily. It phosphorylates and inhibits CDK1. WEE2 may act as a negative regulator of entry into mitosis (G2 to M transition). WEE2 is conserved from yeast to humans. The aim of the present study was to determine the spatiotemporal expression pattern and the function of WEE2 during oocyte maturation in a nonhuman primate species, the rhesus macaque. Taking the long double-stranded RNA-mediated RNA interference approach, down-regulation of WEE2 led to meiotic resumption in a subset of GV oocytes even in the presence of a phosphodiesterase 3 inhibitor. Overexpression of WEE2 delays the reentry of oocytes into meiosis in both mice and monkeys. WEE2 is a conserved oocyte-specific meiosis inhibitor that functions downstream of cAMP in nonhuman primates.
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Western blot analysis of WEE2 (GB113669) at dilution of 1: 600 |
Aliases for WEE2 Gene
