Anti-Lamin B Receptor antibody, affinity-purified (rabbit polyclonal)
Product#: FNK-70-301
$292.34
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Anti-Lamin B Receptor antibody, affinity-purified (rabbit polyclonal)
General information
| Cat. No. | ：FNK-70-301 |
| Size | ：50 µg |
| Antigen | ：Highly purified recombinant mouse LBR (amino acids 1-81) |
| Antibody | ：Affinity-purified with the recombinant LBR |
| Host Species | ：Rabbit |
| Form | ：1.0 mg/ml in PBS, 50% glycerol |
| Purification | ：Affinity Purified |
| Reactivity | ：Mouse and human. Not tested with other species |
| Application | ：Western blotting (0.2~1 ug /ml) ：Immunoprecipitation. ：Indirect immuno-fluorescence staining ：Other applications were not tested |
| Storage | ：Shipped at 4℃ or -20℃ and stored at -20℃ |
Description
Lamins are nuclear membrane proteins that serve to maintain nuclear structure and functions. Lamin B receptor (LBR) is localized in the nuclear envelope inner membrane and anchors the lamina and heterochromatin to the membrane (1). It may mediate interaction between chromatin and lamin B (2). The interaction with lamin and chromatin is regulated by phosphorylation.
| Figure. Identification of LBR in HeLa cell by immuno-precipitation and immuno-staining with anti-LBR antibody (1-81) A) Identification of LBR in crude extract of HeLa cells by immuno-precipitation followed by western blotting B) Indirect immuno-fluorescence staining of HeLa cells |
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References
1. Worman HJ, et al (1988) A lamin B receptor in the nuclear envelope. Pro.Natl.Acad.Sci. USA 85:8531
2. Pyrpasopoulou A, et al. (1996) The lamin B receptor (LBR) provides essential chromatin docking sites at the nuclear envelope. EMBO J. 15: 7108-19
2. Pyrpasopoulou A, et al. (1996) The lamin B receptor (LBR) provides essential chromatin docking sites at the nuclear envelope. EMBO J. 15: 7108-19
Aliases for LBR Gene
- Lamin B Receptor 2 3 5
- Integral Nuclear Envelope Inner Membrane Protein 3 4
- 3-Beta-Hydroxysterol Delta (14)-Reductase 3 4
- Delta(14)-Sterol Reductase LBR 3 4
- Tudor Domain Containing 18 2 3
- C-14 Sterol Reductase 3 4
- Sterol C14-Reductase 3 4
- Delta-14-SR 3 4
- DHCR14B 2 3
- TDRD18 2 3
- C14SR 3 4
- LMN2R 3 4
- Delta(14)-Sterol Reductase 3
- Lamin-B Receptor 4
- EC 1.3.1.70 4
- PHASK 3
- PHA 3
- LBR 5
