Anti Human PXR-2 common mouse monoclonal antibody (H0502)
Anti Human PXR-2 common mouse monoclonal antibody (H0502)
PXR: Pregnane X receptor, SXR
General information
| Cat. No. | ：FNK-PP-H0502-00 |
| Size | ：100 ul |
| Antigen Species | ：Human |
| Host Species | ：Mouse |
| Cross Reactivity | ：Human |
| Purification | ：Ammonium sulfate fractionation. |
| Clone No | ：H0502 |
| Lot. | ：A-2 |
| Concentration | ：1 mg/mL |
| Ig Class | ：G2b |
| Nomenclature | ：NR1I2 |
| Application | ：ELISA : 0.5ug/mL (A450=1.0) ：Western Blot : 1-10ug/mL ：Non reducing Western Blot: 3-10ug/mL |
| Specificity |
：This antibody specifically recognizes human PXR-2 but does not recognize human PXR-1.
Not yet tested in other species. |
| Storage | ：Store at 2 - 8 ºC up to one month. For long-term storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in a frost-free freezer is not recommended. |
| Form | ：Physiological saline with 0.1% NaN3 as a preservative |
| Genbank | ：AF084644 |
Description
Pregnane-activated receptor (PXR,SXR, PAR, PAR1, PAR2, NR1I2) is a member of nuclear receptor subfamily , which each orthologues historically given different names as pregnane-activated receptor in mice and steroid- and xenobiotic-sensing nuclear receptor in human, PXR binds to rifampicin (an antibiotics) is the most efficient activator in human. Various studies revealed PXR regulates CYP3A gene expression as well as other xenobiotic metabolisms, such as oxidation, conjugation and transport. Many chemicals are known to bind for PXR as activators, eg. the HIV protease inhibitor ritonavir, the anticancer drug paclitaxel, the endocrine disruptor bisphenol A. Expression of PXR founds in the liver, small intestine and colon in the human, rabbit and mouse where CYP3A genes are expressed or induced.
Origin
Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human PXR-2(1-78 aa) .
Note
Aliases for NR1I2 Gene
- Nuclear Receptor Subfamily 1 Group I Member 2 2 3 4 5
- Orphan Nuclear Receptor PXR 2 3 4
- Pregnane X Receptor 2 3 4
- PXR 2 3 4
- SXR 2 3 4
- Steroid And Xenobiotic Receptor 3 4
- Orphan Nuclear Receptor PAR1 3 4
- ONR1 2 3
- PAR2 2 3
- BXR 2 3
- Nuclear Receptor Subfamily 1, Group I, Member 2 2
- Pregnane X Nuclear Receptor Variant 2 3
- NR1I2 5
- PAR1 3
- PARq 3
- PAR 3
- PRR 3
- SAR 3
