Anti-Cytokeratin 17 Rabbit Polyclonal Antibody
Anti-Cytokeratin 17 Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB11363 |
| Size | ：100 uL |
| Protein full name | ：Keratin, type I cytoskeletal 17 |
| Synonym | ：Cytokeratin-17, CK-17, Keratin-17, Krt1-17, Krt17, K17, keratin 17 epitope S1, PCHC1, PC2 |
| Immunogen | ：KLH conjugated Synthetic peptide corresponding to Mouse Cytokeratin 17 |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Subcellular location | ：Cytoplasm |
| Predicted MW. | ：48 kDa |
| Observed MW. | ：48 kDa |
| Uniprot ID | ：Q9QWL7, Q04695, Q6IFU8 |
| Storage | ：Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| WB | Human, Mouse | 1: 500-1: 1000 |
skin |
| IHC | Human, Rat | 1: 500-1: 800 | skin |
| IF | Human, Rat | 1: 500-1: 2000 | skin |
Description
Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors.
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Western blot analysis of Cytokeratin 17 (GB11363)at dilution of 1: 600. Lane 1: Hela cell lysate Lane 2: A431 cell lysate Lane 3: HACAT cell lysate Lane 4: Mouse skin tissue lysate |
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Immunohistochemistry analysis of paraffin-embedded mouse skin using Cytokeratin 17 (GB11363) at dilution of 1: 1000. |
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Immunohistochemistry analysis of paraffin-embedded rat skin using Cytokeratin 17 (GB11363) at dilution of 1: 1000. |
Aliases for Cytokeratin 17 Gene
