Anti-Cytohesin 3 Rabbit Polyclonal Antibody
Product#: SB-GB112389
$560.00
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Anti-Cytohesin 3 Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB112389 |
| Size | ：100 uL |
| Protein full name | ：Cytohesin-3 |
| Synonym | ：ARF nucleotide-binding site opener 3, Protein ARNO3, General receptor of phosphoinositides 1, Grp1, PH, SEC7 and coiled-coil domain-containing protein 3, CLM3, SEC7 homolog C, mSec7-3, Pscd3, Cyth3 |
| Immunogen | ：Recombinant protein corresponding to Mouse Cytohesin 3 |
| Isotype | ：IgG |
| Predicted MW. | ：46 kDa |
| Observed MW. | ：46 kDa |
| Purity | ：Affinity purification |
| Uniprot ID | ：O43739, O08967 |
| Storage | ：Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Shipping Condition | ：Dry Ice |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| WB | Human, Mouse, Rat | 1: 250-1: 500 | lung, testis |
Description
GRP1 (general receptor for phosphoinositides-1) contains a Pleckstrin homology (PH) domain as well as a Sec7 domain. The PH domain has high binding affinity for phosphatidylinositol 3,4,5-trisphosphate Ptdlns(3,4,5)P3), while the Sec7 homology domain is responsible for catalyzing guanine nucleotide exchange of ADP-ribosylation factor (ARF) proteins. GRP1 co-localizes with ARF6 and catalyzes GTP/GDP exchange on ARF6. It is known to interact with Ptdlns(3,4,5)P3 localized to the plasma membrane in vitro and may also be a Ptdlns(3,4,5)P3 receptor. Additionally, GRP1 may regulate protein sorting and membrane trafficking through interaction with the guanosine triphosphate ARF, and may control cell adhesion through interaction with integrins.
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Western blot analysis of Cytohesin 3 (GB112389) at dilution of 1: 500 Lane 1: U251 cell lysate Lane 2: Mouse lung tissue lysate Lane 3: Mouse testis tissue lysate Lane 4: Rat lung tissue lysate Lane 5: Rat testis tissue lysate |
Aliases for CYTH3 Gene
- GeneCards Symbol: CYTH3 2
- Cytohesin 3 2 3 5
- Cytohesin-3 2 3 4 5
- ARNO3 2 3 4 5
- GRP1 2 3 4 5
- PSCD3 3 4 5
- PH, SEC7 And Coiled-Coil Domain-Containing Protein 3 3 4
- Pleckstrin Homology, Sec7 And Coiled-Coil Domains 3 2 3
- General Receptor Of Phosphoinositides 1 3 4
- ARF Nucleotide-Binding Site Opener 3 3 4
- Protein ARNO3 4
- Grp1 4
References
- Jux, Bettina, et al. “Cytohesin-3 Is Required for Full Insulin Receptor Signaling and Controls Body Weight via Lipid Excretion.” Nature News, Nature Publishing Group, 5 Mar. 2019, www.nature.com/articles/s41598-019-40231-3.
- Cyth3 Cytohesin 3 [Homo Sapiens (Human)] - Gene - NCBI.” National Center for Biotechnology Information, U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/gene?Cmd=DetailsSearch&Db=gene&Term=9265.
- Account - Genecards Suite, www.genecards.org/cgi-bin/carddisp.pl?gene=CYTH3.
