Anti-Carboxypeptidase B2 Rabbit Polyclonal Antibody
Product#: SB-GB112431
$560.00
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Anti-Carboxypeptidase B2 Rabbit Polyclonal Antibody
General information
| Cat. No. | ：SB-GB112431 |
| Size | ：100 uL |
| Protein full name | ：Carboxypeptidase B2 |
| Synonym | ：Carboxypeptidase R, CPR, Carboxypeptidase U, CPU, Thrombin-activable fibrinolysis inhibitor, TAFI, Cpb2 |
| Immunogen | ：KLH conjugated Synthetic peptide corresponding to Mouse Cpb2 |
| Isotype | ：IgG |
| Purity | ：Affinity purification |
| Subcellular location | ：Secreted |
| Uniprot ID | ：Q96IY4 |
| Storage | ：Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Shipping Conditon | ：Dry Ice |
| Storage Buffer | ：PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
Application
| Applications | Species | Dilution | Positive Tissue |
| IHC | Human | 1: 600-1: 1200 | liver |
Description
This protein belongs to a family of Zn-containing metallocarboxypeptidases specific to C-terminal lysine and arginine residues. It circulates in plasma as a zymogen with molecular weight of 55 kDa (401 amino acid residues; pI 5.0). Being activated by thrombin-thrombomodulin complex during blood coagulation, it exerts carboxypeptidase activity.
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Immunohistochemistry analysis of paraffin-embedded human liver using Cpb2 (GB112431) at dilution of 1: 1200 |
Human Diseases
- Thrombosis: Involved in the regulation of fibrinolysis; dysregulation can contribute to thrombotic disorders.
- Cancer: Elevated levels may correlate with tumor progression and metastasis due to its role in the coagulation cascade.
- Cardiovascular Diseases: Implicated in conditions related to abnormal clot formation and vascular health.
- Renal Disorders: Associated with renal tubular acidosis due to its enzymatic functions affecting electrolyte balance.
Cellular Signaling Pathways
- Activated by thrombin, leading to the inhibition of fibrinolysis by cleaving C-terminal residues of fibrin, which are crucial for plasminogen activation.
- Modulates the coagulation cascade and influences platelet aggregation and vascular repair processes.
- Interacts with various substrates involved in inflammation and tissue remodeling, impacting wound healing and fibrosis.
Aliases for CPB2 Gene
- GeneCards Symbol: CPB2 2
- Carboxypeptidase B2 2 3 4 5
- PCPB 2 3 4 5
- TAFI 2 3 4 5
- CPU 2 3 4 5
- Carboxypeptidase B2 (Plasma, Carboxypeptidase U) 2 3
- Thrombin-Activatable Fibrinolysis Inhibitor 2 3
- Thrombin-Activable Fibrinolysis Inhibitor 3 4
- Carboxypeptidase B2 (Plasma) 2 3
- Plasma Carboxypeptidase B 2 4
- Carboxypeptidase U 2 4
- Carboxypeptidase R 2 3
- EC 3.4.17.20 4 49
- Carboxypeptidase B-Like Protein 3
- EC 3.4.17 49
References
- Human Carboxypeptidase B2/CPB2 Elisa Kit.” Human Carboxypeptidase B2/CPB2 ELISA Kit - Invitrogen, www.thermofisher.com/elisa/product/Human-Carboxypeptidase-B2-CPB2-ELISA-Kit/EH68RB.
- Leenaerts D;Loyau S;Mertens JC;Boisseau W;Michel JB;Lambeir AM;Jandrot-Perrus M;Hendriks D; “Carboxypeptidase U (CPU, Carboxypeptidase B2, Activated Thrombin-Activatable Fibrinolysis Inhibitor) Inhibition Stimulates the Fibrinolytic Rate in Different in Vitro Models.” Journal of Thrombosis and Haemostasis?: JTH, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/30053349/.
- RA;, Matthews KW;Mueller-Ortiz SL;Wetsel. “Carboxypeptidase N: A Pleiotropic Regulator of Inflammation.” Molecular Immunology, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/14687935/.
- Leenaerts D;Aernouts J;Van Der Veken P;Sim Y;Lambeir AM;Hendriks D; “Plasma Carboxypeptidase U (CPU, CPB2, Tafia) Generation during in Vitro Clot Lysis and Its Interplay between Coagulation and Fibrinolysis.” Thrombosis and Haemostasis, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/28692110/.
