Altemicidin (Acaricidal and Antitumor)
Product#: FNK-12151
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Altemicidin (Acaricidal and Antitumor)
Specifications
Code No.: 12151
CAS#: 125399-82-8
Molecular Formula: C13H20N4O7S
Molecular Weight: 376.384
Source: Streptomyces sp. MI944-61F6
Appearance: white powder
Purity: > 90%(Quantitative NMR)
Long Term Storage: at -20 °C
Solubility: Soluble in H2O. Poorly soluble in MeOH. Insoluble in acetone, hexane.
CAS#: 125399-82-8
Molecular Formula: C13H20N4O7S
Molecular Weight: 376.384
Source: Streptomyces sp. MI944-61F6
Appearance: white powder
Purity: > 90%(Quantitative NMR)
Long Term Storage: at -20 °C
Solubility: Soluble in H2O. Poorly soluble in MeOH. Insoluble in acetone, hexane.
Application Notes
Altemicidin is a natural product obtained from Streptomyces sioyaensis, SA-17588.1,2) Altemicidin showed
antitumor activity. It inhibited the growth of L1210 tumor cell (IC50: 0.84 μg/mL) and IMC carcinoma cell
(IC50: 0.82 μg/mL). 1) It also showed inhibitory activity against Xanthomonas oryzae (MIC: 6.25 μg/mL).1)
Its LC50 value against brine shrimp was 3.0 μg/mL.1) Altemicidin has activity against the two spotted spider
mite on kidney bean leaves and the 50% prevention value is about 10 ppm.1) Altemicidin analogues have
been found from streptomyces as isoleucyl tRNA synthetase inhibitor.3)
References
- Altemicidin, a new acaricidal and antitumor substance. I. Taxonomy, fermentation, isolation and
physico-chemical and biological properties. Takahashi A, et al. J Antibiot. 1989 42(11) 1556-1561. - Altemicidin, a new acaricidal and antitumor substance. II. Structure determination. Takahashi A, et al. J
Antibiot. 1989 42(11) 1562-1566. - SB-203207 and SB-203208, Two nobel isoleucyl tRNA synthetase inhibitors from a streptomyces sp. I .
Fermentation, isolation and properties. Stefanska A.L., et al. J Antibiot. 2000 53(4) 357-363.
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