Pteropodine (Uncarine C)

Pteropodine (Uncarine C)
 

• CAT Number : FNK-2400239
• CAS Number : 5629-60-7
• Molecular Weight : 368.43
• Molecular Formula : C₂₁H₂₄N₂O₄
• Pack size: 5 mg
• Store: Store at 2-10℃ in a dry and dark place.
• Purity: (HPLC) ≥98％

Product description
Pteropodine, also known as Uncarine C, is a heterohimbine-type oxindole alkaloid primarily isolated from 'Cat's claw' (Uncaria tomentosa). It is a natural product with various biological activities and potential medicinal properties.

Properties

• Chemical formula: C₂₁H₂₄N₂O₄
• Molecular weight: 368.43 g/mol
• Appearance: Likely a white to off-white crystalline powder
• CAS number: 5629-60-7
• Solubility: Likely soluble in organic solvents

Applications and usage

• Neuropharmacological research, particularly for muscarinic M1 and 5-HT2 receptor modulation
• Antigenotoxic and antioxidant studies
• Cancer research, including studies on medullary thyroid carcinoma, acute lymphoblastic leukemia, and ovarian carcinoma
• Anti-inflammatory investigations
• Natural product research and discovery
• Potential neuroprotective, anticancer, and antihypertensive applications

Safety and handling

• Use appropriate personal protective equipment
• Store in a cool, dry place in tightly closed containers
• Handle with care and avoid skin contact or inhalation
• Treat as a potentially hazardous research chemical

Involved human diseases

Anti-inflammatory Effects
Pteropodine demonstrates significant anti-inflammatory properties:
It can decrease the frequency of sister-chromatid exchanges and micronucleated polychromatic erythrocytes in mice administered doxorubicin, indicating a protective effect against genetic damage1.
Studies in rodent models show pteropodine reduces inflammation in arthritis and induced edema.
It inhibits pro-inflammatory markers like NF-κB and interleukin-6 (IL-6).

Antioxidant Activity
Pteropodine exhibits strong antioxidant capabilities:
It shows a potent capacity to scavenge free radicals, with 98.26% DPPH radical trapping at 250 μg/ml concentration.
This antioxidant effect may contribute to its protective properties against cellular damage.

Immune System Modulation
Research indicates pteropodine can influence immune function:
It increased lymphocyte production by 25.8% over control values in a 96-hour assay.
Studies suggest it may encourage proliferation of myeloid precursor cells.

Potential Neuroprotective Effects
Some evidence points to possible benefits for neurological conditions:
Cat's claw extracts containing pteropodine have shown promise in reducing beta-amyloid plaques and tau protein tangles associated with Alzheimer's disease in animal models.
Components of cat's claw extract, including pteropodine, were found to cross the blood-brain barrier rapidly in rodent studies.

Anti-cancer Potential
While more research is needed, some studies indicate possible anti-cancer properties:
Pteropodine and other alkaloids from cat's claw have demonstrated antioxidant and anti-neoplastic activities in laboratory studies.

Cellular Signaling Pathways Affected

NF-κB pathway:
Pteropodine inhibits the activation of nuclear factor kappa B (NF-κB), a major transcription factor involved in inflammatory responses.

MAPK pathway:
It modulates the mitogen-activated protein kinase (MAPK) signaling pathway, which is linked to inflammation and cell proliferation.

Cytokine signaling:
Pteropodine reduces the expression of pro-inflammatory cytokines like interleukin-6 (IL-6).

Akt/mTOR pathway:
Studies suggest it may affect the Akt/mTOR signaling pathway, which is involved in cell growth and survival.

JAK/STAT pathway:
There is evidence that pteropodine influences the JAK/STAT signaling pathway, important for immune function and cell growth.

Antioxidant pathways:
It exhibits strong antioxidant capabilities, likely modulating cellular antioxidant defense pathways.

Apoptosis pathways:
Pteropodine has shown potential to induce apoptosis in certain cell types, suggesting effects on apoptotic signaling pathways.

Immune cell signaling:
It enhances lymphocyte production and may affect myeloid precursor cell proliferation, indicating modulation of immune cell signaling