Probestin, Aminopeptidase M Inhibitor, Aminopeptidase N Inhibitor
Cat.No.: FNK-00367
Size: 1 mg
Storage: -20°C
CAS: 123652-87-9
Specifications
Molecular Formula : C26H38N4O6
Molecular Weight : 502.612
Source : Streptomyces sp.
Supplied as : Powder
Purity : > 90% (HPLC)
Long Term Storage : at -20 °C
Solubility : Soluble in H2O, MeOH, DMSO
Description:
M.W.: 502.612 Purity : >90% (HPLC) Molecular Formula : C26H38N4O6 Solubility : Soluble in H2O, MeOH, and DMSO It was reported that probestin strongly inhibited Aminopeptidase M (AP-M, AP-N) (IC50=0.030μg/ml). It had no antimicrobial activity at 100 μg/ml and had low toxicity (LD50 > 250 mg/kg: mice iv injection).
Application Notes
Probestin, having a proline-proline sequence in its structure, was isolated from fermentation broth ofStreptomyces azureus MH663-2F6.1, 2) It inhibited aminopeptidase M (IC50= 0.030 μg/ml), anenkephalin inactivating enzyme, in cerebral membranes.1) It had no antimicrobial activity at 100 μg/mland had low toxicity (LD50 > 250 mg/kg: mice iv injection).1)
References
1) Probestin, a new inhibitor of aminopeptidase M, produced by Streptomyces azureus MH663-2F6. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. Aoyagi T, et al. J Antibiot. 1990 43(2) 143-148.
2) Probestin, a new inhibitor of aminopeptidase M, produced by Streptomyces azureus MH663-2F6. II. Structure determination of probestin. Yoshida S, et al. J Antibiot. 1990 43(2) 149-153.
