Cell permeable, irreversible inhibitor of gastric and pancreatic lipases. Shows only minimal activity against amylase, trypsin, chymotrypsin, or phospholipase A2 (PLA2). Partially inhibits the hydrolysis of triglycerides and lowers the absorption of dietary fat and promotes weight loss. Anti-obesity drug. Exhibits antitumor activity by inhibition of the thioesterase domain of fatty acid synthase (FAS) both in vitro and in vivo.

CAS Registry Number: 96829-58-2

CA Index Name: 【Tetrahydrolipstatin】【N-Formyl-Lleucine-(1S)-1-(((2S,3S)-3-hexyl-4- oxo-2-oxetanyl)methyl)dodecyl Ester】

Appearance: white solid

Molecular Formula/ Weight: C₂₉H₅₃NO₅=495.74

Melting Point: 41-42℃

Solubility: Soluble in 1mg/ml ethanol, methanol, DMSO

Handling and Storage: Store at -20℃.

References:

1. A. Lookene, et al.; Eur. J. Biochem. 222, 395 (1994)
2. B. Sternby, et al.; Clin. Nutr. 21, 395 (2002)
3. L.M. Knowles, et al.; J. Biol. Chem. 279, 30540 (2004)