CAS# : 181427-78-1 Molecular Formula : C13H12O6 Molecular Weight : 264.233 Source : Chemically synthesized Supplied as : Powder Purity : >98 % (HPLC) Long Term Storage : at -20 °C Solubility : Soluble in MeOH, DMSO Synonym : 2-(8-hydroxy-6-methoxy-1-oxo-1 H-isochromen-3-yl)propanoic acid
Application Notes
NM-3 is a biologically stable synthetic analogue of cytogenin. Oral administration of NM-3 (0.310mg/kg/day) to mice dose-dependently suppressed angiogenesis induced by S-180 tumor cells. The combined treatment with NM-3 and chemo therapeutic agents (including 5-FU, docetaxel and ionizing radiation) significantly reduced mean tumor volume (including HT29, MKN28, MCF-7, LLC and A549) compared to either treatment alone, with no effects on body weight changes.
References
1) Synthesis and biological evaluation of cytogenin derivatives. Matsumoto N, et al. J Antibiot. 2001 54(3) 285-296.
2) Convenient total synthesis of NM-3, an antiangiogenesis agent, and its optical resolution. Tsuchida T, et al. J Antibiot. 2003 56(1) 38-41.
3) Inhibition of angiogenesis by a new isocoumarin, NM-3. Nakashima T, et al. J Antibiot. 1999 52(4) 426-428.
4) NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity. Salloum RM, et al. Cancer Res. 2000 60(24) 6958-6963.
5) Antineoplastic effects of chemotherapeutic agents are potentiated by NM-3, an inhibitor of angiogenesis. Reimer CL, et al. Cancer Res. 2002 62(3) 789-795.
6) The angiogenesis inhibitor NM-3 is active against human NSCLC xenografts alone and in combination with docetaxel. Agata N, et al. Cancer Chemother Pharmcol. 2005 56(6) 610-614.
