Monoclonal Antibody Against Human Blood Group N (5354)
Product#: FNK-2AHBGN1
$260.92
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Monoclonal Antibody Against Human Blood Group N (5354)
| Cat. No: | FNK-2AHBGN1 |
| Clone No: | Hyb-5354 |
| Manufacturing Process: | Hybridoma obtained by fusing mouse myeloma cells (NS-1) with BALB/c mouse spleen cells immunized with human erythrocyte is proliferated in the BALB/c mouse abdominal cavity and ascites is collected. |
| Specificity: | This monoclonal antibody specifically agglutinates human blood group N red blood cells. |
| Purification: | Ammonium sulfate precipitation. |
| Ig Class: | IgG1 |
| Form: | Saline (containing 0.1% NaN3) |
| Protein Concentration: | 0.5 mg/mL |
| Package: | 0.2 mL |
| Storage: | 2-8℃ (Below -20℃ for long term storage) |
| Shipping Condition: | Dry Ice |
| Application: | Hemagglutination |
Antigen Characterization
- Type: Primary
- Application:ELISA , Western Blot
- Species:Human
- Recombinant:Yes
Human Diseases
- Hemolytic Disease of the Newborn (HDN): Caused by incompatibility between maternal and fetal blood groups, where maternal antibodies against the N antigen attack fetal red blood cells.
- Transfusion Reactions: Can occur if incompatible blood is transfused.
Cellular Signaling Pathways
- Erythrocyte Membrane Dynamics: The N antigen is involved in cell signaling pathways that regulate erythrocyte membrane stability and interactions.
- Immune Response Modulation: Plays a role in modulating immune responses through receptor-ligand interactions.
Aliases for Blood Group N Gene
- N antigen
- MNSs system antigen (part of the MNS blood group system)
References
- MNSS Blood Group System.” Encyclopædia Britannica, Encyclopædia Britannica, inc., www.britannica.com/science/MNSs-blood-group-system.
- Saison, Ruth. “N Blood Group System of Pigs.” Nature News, Nature Publishing Group, www.nature.com/articles/211768a0.
- NHS Choices, NHS, www.nhs.uk/conditions/blood-groups/.
