Monoclonal Antibody Against Human Blood Group M (8052)
Product#: FNK-2AHBGM1
$260.92
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Monoclonal Antibody Against Human Blood Group M (8052)
| Cat. No: | FNK-2AHBGM1 |
| Clone No: | Hyb-8052 |
| Manufacturing Process: | Hybridoma obtained by fusing mouse myeloma cells (NS-1) with BALB/c mouse spleen cells immunized with human erythrocyte is proliferated in the BALB/c mouse abdominal cavity and ascites is collected. |
| Specificity: | This monoclonal antibody specifically agglutinates human blood group M red blood cells. |
| Purification: | Ammonium sulfate precipitation. |
| Ig Class: | IgG1 |
| Form: | Saline (containing 0.1% NaN3) |
| Protein Concentration: | 0.5 mg/mL |
| Package: | 0.2 mL |
| Storage: | 2-8℃ (Below -20℃ for long term storage) |
| Shipping Condition: | Dry Ice |
| Application: | Hemagglutination |
Antigen Characterization
- Type: Primary
- Application: ELISA , Western Blot
- Species: Human
Human Diseases
- Potential association with increased susceptibility to certain infections:
- Cholera
- E. coli O157
- Possible link to cognitive disorders:
- Increased risk of cognitive impairment in AB blood type individuals (which can include M antigen)
- Potential involvement in:
- Cardiovascular diseases
- Metabolic disorders (e.g., diabetes, obesity)
- Rare cases of hemolytic disease of the newborn
Cellular Signaling Pathways
- Cell Adhesion and Migration: The M antigen is involved in cellular adhesion processes, influencing leukocyte migration during immune responses.
- Glycoprotein Interaction: The M antigen is expressed on glycophorin A, which plays a role in maintaining red blood cell shape and stability, affecting how these cells interact with other cells and components in the bloodstream.
- Immune Response Modulation: The presence of M antigens can modulate immune responses by influencing T cell activation and differentiation.
- Pathogen Interaction: The M antigen may serve as a receptor for certain pathogens, affecting their ability to adhere to host tissues and evade immune detection.
Aliases for Blood Group M Gene
- Blood Group M Antigen
- M Antigen
- Glycophorin A Antigen
- MN Blood Group Antigen
- MNS1
References
- Dean, Laura. “The MNS Blood Group.” Blood Groups and Red Cell Antigens [Internet]., U.S. National Library of Medicine, 1 Jan. 1970, www.ncbi.nlm.nih.gov/books/NBK2274/.
- Dean, Laura. “Blood Group Antigens Are Surface Markers on the Red Blood Cell Membrane.” Blood Groups and Red Cell Antigens [Internet]., U.S. National Library of Medicine, 1 Jan. 1970, www.ncbi.nlm.nih.gov/books/NBK2264/.
- “MNSS Blood Group System.” Encyclopædia Britannica, Encyclopædia Britannica, inc., www.britannica.com/science/MNSs-blood-group-system.
- “Blood Group Antigen.” Blood Group Antigen - an Overview | ScienceDirect Topics, www.sciencedirect.com/topics/medicine-and-dentistry/blood-group-antigen.
- “The Importance of Antigens and Antibodies.” Encyclopædia Britannica, Encyclopædia Britannica, inc., 18 Sept. 2024, www.britannica.com/science/blood-group/The-importance-of-antigens-and-antibodies.
