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Migrastatin

Product#: FNK-10708

$598.00

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Migrastatin

Cat. No. FNK-10708
Size 1 mg
Storage -20 ^oC
CAS 314245-65-3
Molecular Formula C₂₇H₃₉NO₇
Molecular Weight 489.609
Source Streptomyces sp. MK929-43F1
Appearance White powder
Purity > 90% (HPLC)
Solubility Soluble in MeOH, DMSO, DMF. Insoluble in H2O.

Application Notes

Migrastatin inhibits cell migration of human esophageal cancer (EC17) & mouse melanoma (B16) cells 1).
It was found to inhibit anchorage-independent growth of human small cell lung carcinoma (Ms-1) cells 2).

Reference

Migrastatin, a New Inhibitor of Tumor Cell Migration from Streptomyces sp. MK929-43F1. Taxonomy, Fermentation, Isolation and Biological Activities. Nakae K, Yoshimoto Y, Sawa T, Homma Y, Hamada M, Takeuchi T, Imoto M. J. Antibiotics, 2000, 53, 1130-1136.
Migrastatin, a novel 14-membered ring macrolide, inhibits anchorage-independent growth of human small cell lung carcinoma Ms-1 cells. Takemoto Y, Nakae K, Kawatani M, Takahashi Y, Naganawa H, Imoto M. J. Antibiotics, 2001, 54, 1104-1107.
Absolute configuration of migrastatin, a novel 14-membered ring macrolide. Nakamura H, Takahashi Y, Naganawa H, Nakae K, Imoto M, Shiro M, Matsumura K, Watanabe H, Kitahara T. J. Antibiotics, 2002, 55, 442-444

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Natural macrocyclic compounds from microorganisms:

Structural classification	Compound Name	Property / Biological activity	Link
Bacterial proteins/Inhibition of DNA synthesis	Aplasmomycin (Sodium Salt)	Aplasmomycin A Inhibited the growth of gram-positive bacteria including mycobacteria and showed an antimalarial activity in mice infected with Plasmodium berghei.
Bacterial proteins/Inhibition of DNA synthesis	Migrastatin	Migrastatin inhibited metastasis of human esophageal cancer cells and anchorage-independent growth of human small cell lung carcinoma cells.	Current Link
Macrolactams	Bisucaberin	Bisucaberin is a siderophore with iron-affinity and induced concentration dependent macrophage-mediated tumor cell lysis.
Cyclic peptides	Bottromycin A2	Bottromycin A2 showed growth inhibitory activity against gram-positive bacteria, MRSA (Methicillin-resistant Staphylococcus aureus), and VRE (Vancomycin-resistant Enterococci).
	Iturin A-2	Iturin A-2 showed the control of damping-off of tomato (a seedling disease) and cytotoxicity to human breast cancer cell line BT-474.
	Plipastatin A1	Plipastatin A1 inhibited phospholipase A2 and induced ISR (induced-systemic-resistance).
	Phepropeptin A	Phepropeptin A inhibited proteasomal chymotrypsin-like activity.
	Phepropeptin B	Phepropeptin B inhibited proteasomal chymotrypsin-like activity.
	Phepropeptin C	Phepropeptin C inhibited proteasomal chymotrypsin-like activity.
	Phepropeptin D	Phepropeptin D inhibited proteasomal chymotrypsin-like activity.
Cycloalkenes	Rubratoxin A	Rubratoxin A inhibited protein phosphatase 2A (PP2A) in a competitive manner.