Specifications:
Molecular Formula : C18H21N3O4
Molecular Weight : 343.383
Source : Streptomyces thioluteus ME561-L4
Appearance : Powder
Purity : > 95% (HPLC)
Long Term Storage : at – 20 °C
Solubility : Soluble in DMSO, slightly soluble in MeOH
Storage conditions: –20 °C
Application Notes:
Mazethramycin B (mazethramycin 11-methyl ether) was isolated from culture filtrate of Streptomyces thioluteus ME561-L4. The absolute stereochemistry of mazethramycin B was determined by the X-ray diffraction analysis. Mazethramycin B had antimicrobial and antitumor activity. It prolonged the survival period of mice inoculated with leukemia L-1210 ( T/C: 240% at 31.3 μg/kg/day). Mazethramycin B has the pyrrolobenzodiazepine (PBD) structure, which is a class of natural products produced by various actinomycetes. Pyrrolobenzodiazepines (PBDs) are known as sequence-selective DNA alkylating agents with remarkable antineoplastic activity. Ongoing research demonstrates that PBDs can be effectively used for antibody-targeted therapy.
References:
1) Mazethramycin, a new member of anthramycin group antibiotics. Kunimoto S, et al. J Antibiot. 1980 33(6)
665-667.
2) Novel antibiotics mazethramycins and process their preparation. Umezawa H, et al. 1978 JP S53-82792A.
3) The crystal structure data was deposited to the Cambridge Crystallographic Data Centre as CCDC number 2363242.
4) Biosynthesis, Synthesis and Biological Activities of Pyrrolobenzodiazepine. Gerratana B, Med Res Rev. 2012 32(2) 254–
293.
5) What is pyrrolobenzodiazepine (PBD)? The editorial team of ADC Review, March 23, 2019
(https://www.adcreview.com/the-review/cytotoxic-agents/what-is-pyrrolobenzodiazepine-pbd/).
