Magnoflorine Iodide

Cat. No. FNK-NS280602


Features:

Size: 5 mg
CAS #: 4277-43-4
Molecular Formula: C₂₀H₂₄NO₄I
Molecular weight: 469.31
Purity: ≥99% (HPLC)
Storage: 4°C

Product Description
Magnoflorine Iodide is a quaternary aporphine alkaloid naturally occurring in various plants, particularly in Acorus calamus. It is studied for its diverse biological activities and potential therapeutic applications.

Property

• Chemical Formula: C₂₀H₂₄INO₄
• Molecular Weight: 469.31 g/mol 
• Appearance: Likely a white to off-white crystalline powder
• Solubility: Soluble in water and polar organic solvents

Application and Usage

• Research: Used in studies investigating its various biological activities
• Pharmaceutical Development: Investigated for potential therapeutic applications, particularly in Alzheimer's disease
• Antimicrobial Studies: Reduces the formation of C. albicans biofilm
• Enzyme Inhibition: Inhibits matrix metalloproteinase (MMP) activity, specifically MMP-2 and MMP-9

Safety and Handling

• Storage: Store in a cool, dry place, protected from light
• Handling: Use appropriate personal protective equipment
• Safety Measures: Avoid dust formation, breathing mist/gas/vapors, and contact with skin and eyes

Involved Human Diseases

• Neurological Disorders
  • Alzheimer's Disease: Magnoflorine has demonstrated neuroprotective properties and may improve cognitive deficits associated with Alzheimer's disease. It has been shown to mitigate the pathology of Alzheimer's disease by modulating the c-Jun N-terminal kinase (JNK) pathway.
  • Depression: Research suggests that magnoflorine could be a potential drug candidate for the treatment of depression.
• Inflammatory Conditions
  • Magnoflorine exhibits anti-inflammatory properties, which may be beneficial in various inflammatory disorders. It has been shown to ameliorate collagen-stimulated arthritis by inhibiting the inflammatory response through the NF-κB/mitogen-activated protein kinase (MAPK) pathways.
• Diabetes
  • Studies have indicated that magnoflorine possesses anti-diabetic activities. It has shown promise in attenuating diabetic nephropathy by suppressing inflammatory responses and fibrosis.
• Cancer
  • Magnoflorine has demonstrated anticancer potential against several types of cancer:
    • Lung cancer (NCI-H1299 cells)
    • Breast cancer (MDA-MB-468 cells)
    • Glioma (T98G cells)
    • Rhabdomyosarcoma (TE671 cells)
  • In these cancer types, magnoflorine has shown the ability to inhibit proliferation, induce apoptosis, and arrest the cell cycle in S/G2 phases in a dose-dependent manner.
• Cardiovascular Diseases
  • Magnoflorine has shown hypotensive activities, suggesting potential benefits in cardiovascular conditions.
• Fungal Infections
  • The compound has demonstrated antifungal properties, which could be useful in treating certain fungal infections.

Cell Signaling Pathways Affected

• NF-κB Pathway
  • Magnoflorine modulates the NF-κB signaling pathway, which plays a crucial role in inflammation and immune responses. It inhibits the activation of NF-κB by:
    • Suppressing the phosphorylation of p65 and IκBα
    • Affecting IKKα/β phosphorylation, which is involved in IκBα phosphorylation
• MAPK Pathways
  • Magnoflorine influences multiple MAPK pathways, including:
    • ERK1/2
    • JNK1/2
    • p38 MAPK
  • These pathways are involved in cellular processes such as proliferation, differentiation, and stress responses.
• PI3K/Akt/mTOR Pathway
  • Magnoflorine has been shown to affect the PI3K/Akt/mTOR signaling cascade, which is important in cell survival, growth, and metabolism.
• Sirt1/AMPK Pathway
  • In the context of neuroprotection, magnoflorine influences the Sirt1/AMPK pathway, which is associated with energy metabolism and cellular stress responses.
• Autophagy-related Pathways
  • Magnoflorine modulates autophagy-related signaling, as evidenced by its effects on:
    • - LC3-II to LC3-I ratio
    • - p62 expression
    • - Beclin-1 levels
• Apoptosis Pathways
  • Magnoflorine affects apoptotic signaling by:
    • - Suppressing Bcl-2 expression
    • - Increasing Bax expression
    • - Activating caspase-3 and PARP cleavage
• HMGB1/NF-κB Pathway
  • In cancer cells, magnoflorine has been shown to down-regulate HMGB1, which in turn affects the NF-κB pathway, influencing cell survival and drug resistance.