MC-1 Angiogenesis Inhibitor
Product#: FNK-16479
$598.00
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MC-1 Angiogenesis Inhibitor
Cat No.: FNK-16479Description
MC-1, which has an isocoumarin skeleton, is one of the metabolites of cytogenin (# 16331 ), which was discovered in the actinomycete Streptoverticillium eurocidium . It shows the same activity as cytogenin in mouse angiogenesis, but shows higher in vivo stability than cytogenin1). Among the mouse metabolites of cytogenin, MC-1 shows a structure in which the alcohol side chain is oxidized to a carboxylic acid. Interestingly, MC-1 has been reported to be isolated from Aspergillus ochraceus, a fungus known to produce ochratoxin2 ), and from Aspergillus sp., a mangrove endophytic fungus3). * This product is for research use only . It cannot be used for any other purpose.
It can be used not only for drug discovery screening, but also for pharmacological activity tests that utilize various inhibitory effects.
Features
Molecular formula : C11H8O6
Molecular weight: 236.179
Purity: >98% (HPLC)
It dissolves in methanol and DMSO
Storage Conditions: -20℃
Application Notes:
MC-1 is one of the stable metabolites of cytogenin in mice. It had moderate anti-angiogenetic (at 20 mg/kg) and anti-arthritic activity (at 100 mg/kg).
References:
1) Synthesis and biological evaluation of cytogenin derivatives. Matsumoto N, et al. J Antibiot. 2001 54(3) 285-296.
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