Hymeglusin, 1 mg
Product#: FNK-BLK-0450-1mg
$175.41
Availability:
Ships in 1-2 Weeks
Hymeglusin
Cat No:
FNK-BLK-0450-1mg
Product ID and Size
| Cat No. | Description | Size | Link |
| FNK-BLK-0450-100ug | (R,R)-Hymeglusin | 100μg |  |
| FNK-BLK-0450-1mg | (R,R)-Hymeglusin | 1mg | |
| FNK-BLK-0450-5mg | (R,R)-Hymeglusin | 5mg | |
Description
Specific inhibitors of mevalonate biosynthesis were screened with an intact mammalian cell assay (Vero cells). Hymeglusin(1233A, F-244 or L-659,699) was isolated from the culture broth of the fungal strain F-244 and found to be an inhibitor of Vero cell growth in MEM medium containing 2% calf serum, but not in the above medium supplemented with 1mM Mevalonate. The absolute configulation was determined by Chiang et al. The total synthesis of Hymeglusin has been reported by several groups. The first total synthesis was reported by Mori et al.
Origin: Scopulariopsis sp. F-244
CAS Registry Number: 29066-42-0
CA Index Name: (R,R)-Hymeglusin (1233A, F-244)
Appearance: White to off-white solid
Molecular Formula/ Weight: C18H28O5=324.42
Melting Point: 68-71°C
Purity: >95.0% by HPLC
Solubility: Sol. in MeOH, EtOAc, Chloroform, DMSO Inso. in water, Hexane.
Handling and Storage: Store at -20℃.
References:
- H. Tomoda, et al., J. Antibiot., 41, 247 (1988).
- C. C. Aldridge, et al., J. Chem. Soc., (C) 3888 (1971).
- Y. C. Chiang, et al., J. Org. Chem., 53, 4599 (1988).
- H. Kumagai, et al., J. Antiboit., 43, 397 (1990).
- K. Mori, et al., Liebigs Ann. Chem., 1991, 1057 (1991).
- S. Omura, et al., J. Antibiot., 41, 1356 (1987).
- H.Tomoda, et al., Biochem. Biophys. Acta., 922, 351 (1988).
- H. Tomoda, et al., J. Antibiot., 46, 872 (1993).
- H. Nagashima, et al., Life Sciences, 52, 1595 (1993).
- H. Tomoda, et al., J. Org. Chem., 62, 2161 (1997).
- T. Sunazuka, et al., J. Antibiot., 45, 1139 (1992).
- H. Hashizume, et al., Chem. Pharm. Bull., 42, 512 (1994).
- H. Hashizume, et al., Chem. Pharm. Bull., 42, 1272 (1994).
- H. Hashizume, et al., Heterocycles, 38, 1551 (1994).
- H. Hashizume, et al., Chem. Pharm. Bull., 42, 2097 (1994).
- H. Kumagai, et al., J. Antibiot., 45, 563 (1992).
Recently Viewed
No More Sales-Annexin V-Flamma® 552
$99999.00
PQA-18, Immunosuppressor
$358.80
Flamma® 675 Vinylsulfone
$967.52
