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Human ELISA Kit · Immunology
Human Interleukin-17 receptor A(IL17RA) ELISA kit
Sandwich quantitative immunoassay for Human Interleukin-17 receptor A(IL17RA) ELISA kit in human serum, plasma, tissue homogenate available in multiple catalog sizes:
Trial 24T 96T
Note: Please send inquiries regarding Trial 24T orders to support@diagnocine.com.
Detection Range
39-2,500 pg/ml
Sensitivity
9.75 pg/mL
Assay Time
1-5 hours
Sample Volume
50-100 μL
Product specifications
| Uniprot No. | Q96F46 |
| Species | Homo sapiens (Human) |
| Sample types | serum, plasma, tissue homogenate |
| Detection range | 39 pg/ml-2500 pg/ml |
| Sensitivity | 9.75 pg/mL |
| Assay time | 1-5h |
| Sample loading volume | 50-100μL |
| Detection wavelength | 450 nm |
| Assay principle | Sandwich (Quantitative) |
| Data analysis | Standard curve + Curve Expert software |
| Research area | Immunology |
| Storage condition | 2-8°C (see protocol for full details) |
| Shipping condition | 4 °C |
| Shelf life | 6 months |
Human Interleukin-17 receptor A(IL17RA) ELISA kit serum plasma tissue homogenate Immunology Human ELISA
Lead Time
10 business days
Processing + 3-5 days shipping
Availability
In Stock : USA
Worldwide shipping available
Assay principle
Sample prep
Antibody capture
450 nm detection
Standard curve
Quantification
Antibody capture
450 nm detection
Standard curve
Quantification
In this sandwich ELISA, Human Interleukin-17 receptor A(IL17RA) ELISA kit in the sample is captured between a pre-coated capture antibody and a detection antibody. Signal intensity is proportional to analyte concentration. Quantification uses a standard curve fitted with Curve Expert software, covering 39 pg/ml-2500 pg/ml with a minimum detectable dose of 9.75 pg/mL.
For research use only (RUO). Not intended for diagnostic or therapeutic purposes. Validated in human serum, plasma, tissue homogenate matrices only.
Description
This Human IL17RA ELISA Kit was designed for the quantitative measurement of Human IL17RA protein in serum, plasma, tissue homogenates, cell lysates. It is a Sandwich ELISA kit, its detection range is 78 pg/mL-5000 pg/mL and the sensitivity is 19.5 pg/mL.
Alternative Names
CANDF5 ELISA Kit; CD217 ELISA Kit; CD217 antigen ELISA Kit; CDw217 ELISA Kit; CTLA8 ELISA Kit; HIL 17R ELISA Kit; hIL17R ELISA Kit; I17RA_HUMAN ELISA Kit; IL 17 receptor A ELISA Kit; IL 17 receptor ELISA Kit; IL 17RA ELISA Kit; IL-17 receptor A ELISA Kit; IL-17RA ELISA Kit; IL17 ELISA Kit; IL17A receptor ELISA Kit; IL17R ELISA Kit; IL17RA ELISA Kit; IMD51 ELISA Kit; Interleukin 17 receptor A ELISA Kit; Interleukin-17 receptor A ELISA Kit; MGC10262 ELISA Kit
Function
Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A. Receptor for IL17F. Binds to IL17A with higher affinity than to IL17F. Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC. Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi. In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells. Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers. Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense. Receptor for IL17C as part of a heterodimeric complex with IL17RE.; (Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway.
Gene References into Functions
- Human periodontal ligament fibroblasts are a target of Th17, and that IL-17 appears to up-regulate the expression of IL-23 p19 via a homeostatic mechanism involving Akt-, p38 MAPK-, and ERK 1/2-dependent NF-kappaB signalling versus the JNK/AP-1 pathway. PMID: 21145111
- mRNA levels of IL-17, IL-17R and MMP-9 were also higher in the invasive group than in the non-invasive group in human pituitary adenomas. PMID: 21279695
- IL-17/IL-17RA signaling plays an important role in myocardial collagen metabolism in hypertension-induced diastolic dysfunction. PMID: 21530504
- Blockage of IL-17RA with an anti-IL-17RA antibody inhibited the production of IL-6, IL-8, and MMP-3; demonstrate the functional significance of IL-17RA in psoriatic arthritis PMID: 21894442
- IFN-alpha could be associated with the expansion of IL-7Ralpha(low) CD45RA(+) EM CD8(+) T cells in the CMV-uninfected elderly PMID: 22484243
- Data show that IL-17RA, IL-17RC, IL-22R1, ERK1/2 MAPK and NF-kappaB pathways are involved in Th17 cytokine-induced proliferation. PMID: 22898922
- Our results might be helpful for explaining the missing heritability of the psoriasis due to epistasis and provide a deep insight into the important role of the IL23/Th17 pathway in the pathogenesis of psoriasis. PMID: 22909235
- Il-17R SNPs were not associated with psoriatic arthritis susceptibility in northern Italians. PMID: 22955875
- Two polymorphisms within the IL17E and IL17RA genes are associated with ESRD independent of age and sex. PMID: 23147652
- IL-17A/IL-17RA interaction promoted the metastasis of OS in nude mice. PMID: 23192273
- Data suggest that the interleukin 17 receptor A (IL17RA) minor alleles of the three single nucleotide polymorphisms (SNP) may decrease the risk of Aspirin Exacerbated Respiratory Disease (AERD) via attenuation of IL17RA gene expression. PMID: 23220496
- protein levels of IL-17 and IL-17R positively correlated with the frequency of seizures in focal cortical dysplasias patients patients. PMID: 23334598
- Our data indicates that serum IL-17 levels are significantly increased in intractable Graves disease and affected thyrocytes show functional IL-17R expression. PMID: 23501056
- crystal structures of homodimeric IL-17A and its complex with IL-17RA, are reported. PMID: 23695682
- polymorphism of IL-17R plays no significant role in incidence of chronic periodontitis and Periimplantitis. PMID: 23852838
- Data show that the interleukin (IL)-17 receptor IL-17RA variant is generated by spliced out of exon 11 encoding the transmembrane region in a variety of tissues. PMID: 24084331
- Whereas no association was found between the alternative splicing SNP, rs6897932, and multiple sclerosis, a significant link was found between the promoter single nucleotide polymorphism, rs11567685, and the disease. PMID: 24166352
- The increased IL-25 levels in plasma and the expression of IL-17RA and IL-17RB on eosinophils in allergic asthma patients suggests that IL-25 may activate eosinophils during allergic inflammation. PMID: 24247484
- Genetic variation in interleukin-17 receptor A is functionally associated with chronic rejection after lung transplantation. PMID: 24263024
- IL17-dependent retinal degeneration in a mouse model of focal retinal degeneration can be prevented by gene therapy with adeno-associated virus vector encoding soluble IL17 receptor PMID: 24780906
- Interleukin-17 receptor A crystal structure shows that the downstream motif of IL-17RA SEFIR together with helix alpha C could provide a composite ligand-binding surface for recruiting Act1 during IL-17 signaling. PMID: 24816115
- IL-17R was almost exclusively expressed by endothelial cells, not by myeloma cells in the masses of skeletal extramedullary disease patients. PMID: 24916639
- IL17RA polymorphisms, but not those of IL17, can influence both the development and the bilaterality of papillary thyroid carcinoma PMID: 25484349
- genetic polymorphism is associated with a reduced renal filtration rate, and with the risk of developing end stage renal disease in healthy elderly from Spain PMID: 25636567
- Both genetic variants of IL-17R (rs882643 and rs2241049) were associated with PGD. This confirms a genetic predisposition toward PGD and suggests a role of IL-17 in driving neutrophilia in PGD. PMID: 25935436
- The presence of IL7R polymorphisms seems to be related to severe liver disease in HIV/hepatitis c virus coinfected patients. PMID: 26123260
- In vitro, CSE stimulation significantly increased IL-17F and IL-17R in 16HBE (2.5%) and A549 (5%) while IL-17A and IL-17F in PBMC (10%). IL-17A and CSE stimulation, rather than CSE or rhIL-17A alone, increased proliferation in 16HBE and apoptosis in A549 PMID: 26198032
- High IL-17RA expression is associated with Intrahepatic Cholangiocarcinoma. PMID: 26228109
- Increased expression of IL-17RA plays an important role in gastric cancer progression, migration and prognosis. PMID: 26261590
- Identified the IL17RA rs4819554 SNP as a risk factor for psoriasis. PMID: 26347322
- expression of immunoreactivity for IL-17A, IL-17RA, IL-17E, and IL-17F was significantly elevated in prostatic tissue from benign prostatic hyperplasia and prostate cancer compared with that in controls PMID: 26356122
- The data indicate that the genetic variants of rs2275913 in IL-17A, rs763780 in IL-17F, and rs4819554 in IL-17RA may not play a role in the pathogenesis of preeclampsia in Chinese Han women. PMID: 26451724
- IL-17 receptor A and adenosine deaminase 2 deficiency due to deletion mutations was found in siblings with chronic mucocutaneous candidiasis and chronic systemic inflammation. PMID: 26607704
- IL17F and IL17RA polymorphisms modulate susceptibility to cerebral malaria(CM) and provide evidence that IL-17F protects against CM. PMID: 26667835
- Results suggest that IL-17-IL-17R interaction in GSCs induces an autocrine/paracrine cytokine feedback loop, which may provide an important signaling component for maintenance/self-renewal of GSCs. PMID: 26755664
- High IL-17RA expression is associated with prostate cancer. PMID: 26871944
- Here, we discuss the latest discoveries on the role of the IL-17A/IL-17RA axis in driving host pulmonary defence and immunopathology. PMID: 27033174
- SNP rs4819554 in promoter is associated with functional severity of ankylosing spondylitis PMID: 27415816
- It has been shown that IL-17 can be produced by enteroendocrine chromogranin A-positive cells as well as by goblet cells in the human colon. PMID: 27660002
- The SNP rs4819554 in the promoter region of IL17RA significantly influences the response to anti-TNF drugs at week 12. PMID: 27670766
- IL-17RA is essential for mucocutaneous immunity to Candida and Staphylococcus, but otherwise largely redundant PMID: 27930337
- cyanidin specifically recognizes an IL-17A binding site in the IL-17A receptor subunit (IL-17RA) and inhibits the IL-17A/IL-17RA interaction. PMID: 28223414
- Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling. PMID: 28298222
- The data connect increased interleukin (IL)-17A/IL-17RA signaling in autism spectrum disorder patients with enhanced oxidative inflammation in monocytes. PMID: 28935156
- Combination of polymorphisms in the NOD2, IL17RA, EPHA2 and KALRN genes could play a significant role in the development of sarcoidosis by maintaining a chronic pro-inflammatory status in macrophages PMID: 29554915
++ 5 more research findings link this target to additional biology. Showing the 45 most recent — the full set appears on the complete datasheet.
Involvement in disease
Immunodeficiency 51 (IMD51)
Tissue Specificity
Widely expressed.
Subcellular Location
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
Database Links
Human Interleukin-17 receptor A(IL17RA) ELISA kit | For research use only | Store 2-8°C | Diagnocine
