Chondroitin sulfate oligosaccharide

Chondroitin sulfate is a polymer substance which consist of alternating units of N-acetyl-Dgalactosamine (GalNAc) and D-glucuronic acid (GlcA). By the microreaction system below, chondroitin sulfate decomposes into low molecules non-enzynatically.

Features

• Sugar composition: mainly 2-12 sugars (mix type)
• Easy to dissolve in water
• Extracted from natural ingredient (ray fish cartilage)

Specification

• Type: Powder
• Chondroitin sulfate amount: >90%
• Moisture: <10%
• pH (1% solution): 3.5-5.5
• Heavy metals: <10 ppm
• General live bacteria: <3,000 cfu/g
• Coliform bacteria: Negative
• Granularity: 30 mesh pass

Application
 

	Fig. 1 : Water-soluble test Each samples were added in water and the dissolve time was measured.
	Fig. 2 : Absorption test using everted sac method (Rat) Our chondroitin sulfate oligosaccarides show excellent water absorbency compared to macromolecule conventional chondroitin sulfate.
	Fig. 3 : Anti-inflammatory test using arthritis model mouse Our chondroitin sulfate oligosaccaride shows excellent recovery from arthritis compared to conventional chondroitin sulfate.

References

• Nishimura, M., et al., The Open Nutrition Journal., 12:10 (2018).
• Shanga, Q., et al., Int. J. of Biological Macromolecules., 89:489 (2016).
• Sakai, S., et al., J. Biol. Chem., 281 (29):19872 (2006) .
• Cho, S.Y., et al., Biol. Pharm. Bull., 27 (1):47 (2004) .
• Igarashi, N., et al., Int. J. of Carbohydrate Chem., 856142:(2013) .