Bis-PEG2-NHS ester

Bis-PEG2-NHS ester

 

• CAT Number : Gly-GMSL-120
• CAS Number : 65869-63-8 
• Molecular Weight : 400.34
• Molecular Formula : C₁₆H₂₀N₂O₁₀
• Pack size: 1 g

Product description
Bis-PEG2-NHS ester is a PEG derivative containing two NHS ester groups connected by a short PEG spacer. It is a non-cleavable linker commonly used in bioconjugation applications, particularly in the synthesis of antibody-drug conjugates (ADCs).

Property

• Molecular Formula: C₁₆H₂₀N₂O₁₀
• Molecular Weight: 400.34 g/mol
• CAS Number: 65869-63-8
• Physical State: Likely a solid at room temperature
• Solubility: The hydrophilic PEG spacer increases solubility in aqueous media

Application and Usage

• Antibody-drug conjugation (ADC): Used as a linker in ADC synthesis
• Bioconjugation: Labels primary amines (-NH2) of proteins, peptides, or other biomolecules
• Cross-linking: Can be used to cross-link two amine-containing molecules
• Increasing aqueous solubility: The PEG spacer enhances solubility of conjugated molecules
• Protein modification: Used to modify proteins for various research applications

Safety and Handling

• Use appropriate personal protective equipment (PPE)
• Handle in a well-ventilated area
• Avoid skin contact and inhalation
• Store in a cool, dry place

Involved Human Diseases
While this compound is not directly associated with treating specific human diseases, its applications in bioconjugation and ADC development may contribute to research and potential treatments for various conditions, particularly in cancer therapy. However, no specific diseases are mentioned for this particular compound.