Anti-Human Apolipoprotein J Antibody, (J-4H8) Biotinylated

Anti-Human Apolipoprotein J Antibody, (J-4H8) Biotinylated

DiagnoCine offers excellent APOLIPOPROTEIN antibodies to researchers studying human induced pluripotent stem cell, mitochondrial dysfunction, pathophysiology, genetic polymorphisms, metabolism, phospholipase A2 activity, cellular surface factor, angiotensin-converting enzyme, nitric oxide synthase activity, amyloidosis, epigenome/metabolome research, sialylation proteoforms, pathogenesis, and progression.

Human diseases include type 1 diabetes, Memory Deficit, hepatitis C virus, Alzheimer's Disease, Osteoporotic Fractures. endoplasmic reticulum stress, atherosclerotic lesions, cancer, multiple sclerosis, Toxic Hetero-oligomers, brain amyloid load, hypertriglyceridemic pancreatitis, Atherosclerosis, Schnauzers, coronary artery disease, psoriasis, cardiac amyloidosis, cardiovascular disease and hypertension, dementia, type 2 diabetes mellitus, toxicity in human neurons, cognitive impairment, atherothrombosis, familial hypobetalipoproteinemia, hyperlipidemia, Parkinson's disease, metabolic syndrome, coronary heart disease, and depression.

APOLIPOPROTEIN antibodies have excellent quality and this highly pure antibody can be adapted for Western Blots, ELISA, Immunohistochemistry, Immunofluorescence research with optimization. 

General information 

Antigen Characterization   

• Involved in various cellular processes:
  • Programmed cell death
  • Lipid transport
  • Membrane protection
    • Acts as a molecular chaperone
  • Prevents protein aggregation
  • Assists in proper protein folding
    • Interacts with the endoplasmic reticulum
    • Participates in the secretory pathway
    • Plays a role in cellular stress responses:
  • Protects cells from damage caused by oxidative stress and heat shock
    • Contributes to intracellular signaling pathways
    • May influence cell survival and proliferation

• Serves multiple functions across different tissues and systems
• Key component of high-density lipoproteins (HDL) and low-density lipoproteins (LDL)
• Plays a role in lipid metabolism and transport
• Acts as a hepatokine:
  • Regulates muscle glucose metabolism
  • Influences insulin sensitivity
  • Contributes to overall glucose homeostasis
    • Functions in the immune system as a complement inhibitor
    • Helps regulate immune responses
    • Protects barrier cells and fluid-tissue interfaces:
  • Including the blood-brain barrier
    • Implicated in various diseases:
  • Alzheimer's disease: May influence amyloid-beta metabolism and clearance
  • Atherosclerosis: Potentially plays a role in cholesterol transport from peripheral tissues to the liver

Aliases for CLU Gene

• Clusterin ^2 3 4 5
• Testosterone-Repressed Prostate Message 2 ^2 3 4
• Sulfated Glycoprotein 2 ^2 3 4
• Apolipoprotein J ^2 3 4
• TRPM-2 ^2 3 4
• SGP-2 ^2 3 4
• KUB1 ^2 3 4
• Complement-Associated Protein SP-40,40 ^3 4
• Complement Cytolysis Inhibitor ^3 4
• Complement Lysis Inhibitor ^2 3
• Ku70-Binding Protein 1 ^3 4
• NA1/NA2 ^3 4
• SP-40 ^2 3
• APOJ ^3 4
• CLU1 ^2 3
• CLU2 ^2 3
• CLI ^3 4
• Clusterin (Complement Lysis Inhibitor, SP-40,40, Sulfated Glycoprotein 2, Testosterone-Repressed Prostate Message 2, Apolipoprotein J) ²
• Epididymis Secretory Sperm Binding Protein ³
• Aging-Associated Gene 4 Protein ⁴
• Aging-Associated Protein 4 ³
• APO-J ³
• TRPM2 ³
• Apo-J ⁴
• AAG4 ³
• SGP2 ³
• CLU ⁵

References 

• Yao, Rao, et al. What Does Serum Glycosylated Apolipoprotein J Mean in a Heart Attack?-----Correlation of Serum Glycosylated Apolipoprotein J with Acute Myocardial Infarction, 20 June 2023, doi:10.1101/2023.06.19.23291631. 
• Moezzi, Seyed-Mohammad-Iman et al. “Apolipoprotein J in Alzheimer's Disease: Shedding Light on Its Role with Cell Signaling Pathway Perspective and Possible Therapeutic Approaches.” ACS chemical neuroscience vol. 11,24 (2020): 4060-4072. doi:10.1021/acschemneuro.0c00637
• Rivas-Urbina, A.; Rull, A.; Aldana-Ramos, J.; Santos, D.; Puig, N.; Farre-Cabrerizo, N.; Benitez, S.; Perez, A.; de Gonzalo-Calvo, D.; Escola-Gil, J.C.; et al. Subcutaneous Administration of Apolipoprotein J-Derived Mimetic Peptide d-[113–122]apoJ Improves LDL and HDL Function and Prevents Atherosclerosis in LDLR-KO Mice. Biomolecules 2020, 10, 829. https://doi.org/10.3390/biom10060829
• de Silva, H V et al. “Apolipoprotein J: structure and tissue distribution.” Biochemistry vol. 29,22 (1990): 5380-9. doi:10.1021/bi00474a025
• Seo, Ji A et al. “Apolipoprotein J is a hepatokine regulating muscle glucose metabolism and insulin sensitivity.” Nature communications vol. 11,1 2024. 24 Apr. 2020, doi:10.1038/s41467-020-15963-w
• Gupta, Veer Bala et al. “Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging.” Alzheimer's & dementia (Amsterdam, Netherlands) vol. 3 18-26. 22 Dec. 2015, doi:10.1016/j.dadm.2015.12.001
• Lumsden, Amanda L., et al. “Apolipoprotein E (APOE) Genotype-Associated Disease Risks: A Phenome-Wide, Registry-Based, Case-Control Study Utilising the UK Biobank.” eBioMedicine, vol. 59, Sept. 2020, p. 102954, doi:10.1016/j.ebiom.2020.102954.