Anti-Human Apolipoprotein F, Mouse Monoclonal (F-C2A)

Anti-Human Apolipoprotein F, Mouse Monoclonal (F-C2A)

DiagnoCine offers excellent APOLIPOPROTEIN antibodies to researchers studying human induced pluripotent stem cell, mitochondrial dysfunction, pathophysiology, genetic polymorphisms, metabolism, phospholipase A2 activity, cellular surface factor, angiotensin-converting enzyme, nitric oxide synthase activity, amyloidosis, epigenome/metabolome research, sialylation proteoforms, pathogenesis, and progression.

Human diseases include type 1 diabetes, Memory Deficit, hepatitis C virus, Alzheimer's Disease, Osteoporotic Fractures. endoplasmic reticulum stress, atherosclerotic lesions, cancer, multiple sclerosis, Toxic Hetero-oligomers, brain amyloid load, hypertriglyceridemic pancreatitis, Atherosclerosis, Schnauzers, coronary artery disease, psoriasis, cardiac amyloidosis, cardiovascular disease and hypertension, dementia, type 2 diabetes mellitus, toxicity in human neurons, cognitive impairment, atherothrombosis, familial hypobetalipoproteinemia, hyperlipidemia, Parkinson's disease, metabolic syndrome, coronary heart disease, and depression.

APOLIPOPROTEIN antibodies have excellent quality and this highly pure antibody can be adapted for Western Blots, ELISA, Immunohistochemistry, Immunofluorescence research with optimization. 

General information 

Antigen Characterization   

• Acts as a lipid-binding protein
• Functions as a natural inhibitor of cholesteryl ester transfer protein (CETP)
• Regulates transfer of cholesteryl esters and triglycerides between lipoproteins
• Synthesized as a larger precursor protein (proApoF)
• Undergoes cleavage by PCSK7, a liver-enriched protease, to produce mature ApoF
• Cleavage occurs after secretion, suggesting limited intracellular functions
• Primary role is in the extracellular environment

• Found in plasma, associated with lipoproteins (particularly LDL and HDL)
• Inhibits CETP activity, preferentially affecting certain lipoprotein interactions
• Influences distribution of cholesterol among different lipoprotein particles
• Impacts cardiovascular health through its role in lipoprotein metabolism
• Plays a role in whole-body cholesterol clearance mechanisms
• Indirectly affects transfer of tissue-derived cholesterol from HDL to other lipoproteins
• Influences liver clearance and excretion of cholesterol

Aliases for APOF Gene

• Apolipoprotein F ^2 3 4 5
• Lipid Transfer Inhibitor Protein ^3 4
• Apo-F ^3 4
• LTIP ^3 4
• APOF ⁵

References  

• Morton, Richard E, and Daniel Mihna. “Apolipoprotein F concentration, activity, and the properties of LDL controlling ApoF activation in hyperlipidemic plasma.” Journal of lipid research vol. 63,2 (2022): 100166. doi:10.1016/j.jlr.2021.100166
• Lagor, William R et al. “The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice.” PloS one vol. 7,2 (2012): e31616. doi:10.1371/journal.pone.0031616
• Liu, Yan, and Richard E Morton. “Apolipoprotein F: a natural inhibitor of cholesteryl ester transfer protein and a key regulator of lipoprotein metabolism.” Current opinion in lipidology vol. 31,4 (2020): 194-199. doi:10.1097/MOL.0000000000000688
• Deprince, Audrey, et al. “Apolipoprotein F Is Reduced in Humans with Steatosis and Controls Plasma Triglyceride?rich Lipoprotein Metabolism.” Hepatology, vol. 77, no. 4, 15 July 2022, pp. 1287–1302, doi:10.1002/hep.32631.
• “Apolipoprotein F Antibody (ABIN7442087).” Apolipoprotein F Antibody (ABIN7442087), www.antibodies-online.com/antibody/6996646/anti-Apolipoprotein+F+APOF+AA+111-314+antibody/. 
• “APOF Apolipoprotein F [Homo Sapiens (Human)] - Gene - NCBI.” National Center for Biotechnology Information, U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/gene/319.
• “Uniprot Website Fallback Message.” UniProt, www.uniprot.org/uniprotkb/Q13790/entry. 
• “Recombinant Human Apolipoprotein F GST (N-Term) Protein.” Novus Biologicals, www.novusbio.com/products/apolipoprotein-f-recombinant-protein_h00000319-p01.
• “Apolipoprotein.” Apolipoprotein - an Overview | ScienceDirect Topics, www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/apolipoprotein.