Anti-BIT1 Rabbit Polyclonal Antibody

The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. 
 

Western blot analysis of BIT1 (GB113740) at dilution of 1: 600

• GeneCards Symbol: PTRH2 ² 
• Peptidyl-TRNA Hydrolase 2 ^2 3 5
• BIT1 ^2 3 4 5
• PTH2 ^2 3 4 5
• CGI-147 ^2 3 5
• CFAP37 ^2 3 5
• Cilia And Flagella Associated Protein 37 ^2 3
• Peptidyl-TRNA Hydrolase 2, Mitochondrial ^3 4
• Bcl-2 Inhibitor Of Transcription 1 ^3 4
• EC 3.1.1.29 ^4 48
• PTH 2 ^3 4
• Bcl-2 Inhibitor Of Transcription ²
• IMNEPD ³
• PTH ³