Anti Human LXR alpha mouse monoclonal antibody (K8607)
Anti Human LXR alpha mouse monoclonal antibody (K8607)
LXR beta: Liver X Receptor beta
General information
| Cat. No. | ：FNK-PP-K8607-00 |
| Size | ：100 ul |
| Antigen Species | ：Human |
| Host Species | ：Mouse |
| Cross Reactivity | ：Human |
| Purification | ：Ammonium sulfate fractionation. |
| Clone No | ：K8607 |
| Lot. | ：A-2 |
| Concentration | ：1 mg/mL |
| Ig Class | ：G2a |
| Nomenclature | ：NR1H3 |
| Application | ：ELISA : 0.3 ug/mL ：Western Blot : 2 ug/mL |
| Specificity | ：This antibody specifically recognizes LXR alpha but does not recognize human LXR beta. Not yet tested in other species. |
| Storage | ：Store at 2 - 8 ºC up to one month. For long-term storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in a frost-free freezer is not recommended. |
| Form | ：Physiological saline with 0.1% NaN3 as a preservative. |
| Genbank | ：U22662 |
Description
Liver X receptor alpha (LXRa, RLD-1; NR1H3) is a member of orphan nuclear receptor. LXRa activator is the naturally occurring compound 22(R)- hydroxycholesterol (22(R)-HC), 20(S)HC, 24-HC, 25- HC, 7a-HC. LXRa is expressed in the liver, kidney and spleen. LXRa has important role in regulating cholesterol metabolism. It is believed that LXR specific agonist may have important medical applications in the regulation of cholesterol homeostasis. LXRa forms heterodimer with RXR.
Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human LXR alpha (2-97 aa) .
Notes
Sodium azide may react with lead and copper plumbing to form explosive metal azides. Flush with large amounts of water during disposal.
Reference
- Watanabe Y, et al. Nuclear Receptor, 1: 1, 2003
Aliases for NR1H3 Gene
