Anti Human FXR mouse monoclonal antibody (A9033A)
Product#: FNK-PP-A9033A-00
$501.52
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Anti Human FXR mouse monoclonal antibody (A9033A)
FXR: Farnesoid X Receptor
General information
| Cat. No. | ：FNK-PP-A9033A-00 |
| Size | ：100 ul |
| Antigen Species | ：Human |
| Host Species | ：Mouse |
| Cross Reactivity | ：Human/ Mouse/ Rat |
| Purification | ：Ammonium sulfate fractionation. |
| Clone No | ：A9033A |
| Lot. | ：A-2 |
| Concentration | ：1 mg/mL |
| Ig Class | ：G2a |
| Nomenclature | ：NR1H4 |
| Application | ：ELISA (0.2 ug/mL),Western Blot (1 ug/mL), Immunohistochemistry (20-40 ug/mL) |
| Specificity |
：This antibody specifically recognizes human FXR and cross reacts with mouse and rat FXR.
|
| Storage | ：Store at 2 - 8 ºC up to one month. For long-term storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in a frost-free freezer is not recommended. |
| Form | ：Physiological saline with 0.1% NaN3 as a preservative |
| Genbank | ：U68233 |
Description
Farnesoid X-activated receptor (FXR, HRR-1, BAR, RIP14; NR1H4) is a member of orphan nuclear receptor. FXR is expressed in liver, intestinal villi, renal tubes and adrenal cortex. FXR is a global regulator of bile acid metabolism. Two genes, cholesterol 7ahydroxylase (CYP7A1) and IBABP (ileal bile acid binding protein), which are implicated in bile acid biosynthesis and recycling, respectively, are target genes of FXR. FXR was shown to be transcriptionally activated by falnesol metabolites such as farnesol itself, juvenile hormone III. FXR binds to DNA only as a heterodimer with RXR.
Origin
Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human FXR (2-126 aa) .
Note
Sodium azide may react with lead and copper plumbing to form explosive metal azides. Flush with large amounts of water during disposal.
References
- Suh JM, et al. Mol Endocrinol. 2006, 20(12): 3412-20
- Qin J, et al. Developmemtal Dynamics. 2007, 236: 810-20
- Higashiyama H, et al. Acta Histochem. 2008; 110: 86-93
- Gineste R, et al. Mol Endocrinol. 2008. [E pub]
Aliases for NR1H4 Gene
- Nuclear Receptor Subfamily 1 Group H Member 4 2 3 4 5
- Bile Acid Receptor 2 3 4
- RIP14 2 3 4
- HRR1 2 3 4
- FXR 2 3 4
- Retinoid X Receptor-Interacting Protein 14 3 4
- Farnesoid X-Activated Receptor 3 4
- RXR-Interacting Protein 14 3 4
- Farnesol Receptor HRR-1 3 4
- HRR-1 2 3
- BAR 3 4
- Nuclear Receptor Subfamily 1, Group H, Member 4 2
- Farnesoid X Nuclear Receptor 3
- Farnesoid X Receptor 2
- PFIC5 3
- NR1H4 5
