5-Bromo-1-naphthoic acid

5-Bromo-1-naphthoic acid
 

Specifications:

• CAT Number : Gly-GMSM-102
• CAS Number : 16726-67-3
• Molecular Weight : 251.08
• Molecular Formula : C₁₁H₇BrO₂
• Pack size: 1 g
• Appearance: White to off-white crystalline solid

 Applications and Usage

Organic Synthesis: Intermediate and building block for the preparation of various pharmaceutical and agrochemical products
Pharmaceuticals: Precursor for synthesizing naphthalene-based derivatives with potential biological activities, such as anti-tumor agents
Dyes and Pigments: Used in the production of dyes and pigments due to its reactive functional groups and aromatic structure

Safety and Handling

Hazards:

• May cause skin and eye irritation
• Harmful if inhaled or swallowed

Personal Protective Equipment (PPE):

• Gloves
• Goggles
• Lab coat

Precautionary Measures:

• Avoid breathing dust or fumes
• Wash hands thoroughly after handling
• Use only in well-ventilated areas

First Aid:

• In case of skin or eye contact, rinse immediately with plenty of water and seek medical attention
• If inhaled or ingested, seek medical attention immediately

Human Diseases

5-Bromo-1-naphthoic acid itself is not directly associated with treating specific human diseases. However, some key points about this compound and related naphthalene derivatives in the context of potential disease treatments include:

• Research applications: 5-Bromo-1-naphthoic acid and similar compounds are often used as intermediates or precursors in organic synthesis and pharmaceutical research. This suggests they may play a role in developing new drug candidates.
• Aryl hydrocarbon receptor (AhR) activity: Some naphthoic acid derivatives like 1,4-Dihydroxy-2-naphthoic acid (1,4-DHNA) have been shown to bind to the aryl hydrocarbon receptor and exhibit anti-inflammatory activity in the gut. This suggests potential applications in treating inflammatory bowel diseases.
• Enzyme inhibition: Certain naphthalene-based compounds have demonstrated inhibitory effects against enzymes like lactate dehydrogenase from parasites such as Babesia microti. This indicates potential antiparasitic applications.
• Anticancer research: Some hydrazide-hydrazone derivatives of related compounds like 5-bromo-2-iodobenzoic acid have been synthesized and studied for potential anticancer activity.
• Neuroprotective effects: Tanshinone I, a natural diterpenoid quinone compound derived from traditional Chinese medicine, has shown neuroprotective effects in some studies.